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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received April 22, 2013
Accepted July 31, 2013

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nucleation behavior of glutathione polymorphs in water

Zhi Chen Leping Dang Shuai Li Hongyuan Wei^†

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China

Korean Journal of Chemical Engineering, October 2013, 30(10), 1939-1945(7), 10.1007/s11814-013-0143-3

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Abstract

Nucleation behavior of glutathione (GSH) polymorphs in water was investigated by experimental method combined with classical nucleation theory. The solubility of α and β forms GSH in water at different temperatures, and the nucleation induction period at various supersaturations and temperatures were determined experimentally. The results show that, in a certain range of supersaturation, the nucleation of β form predominates at relatively higher temperature, while α form will be obtained at lower temperature. The nucleation kinetics parameters of α and β form were then calculated. To understand the crucial role of temperature on crystal forms, “hypothetic” nucleation parameters of β form at 283.15 K were deduced based on extrapolation method. The results show that the interfacial tension, critical free energy, critical nucleus radius and nucleus number of α form are smaller than that of β form in the same condition at 283.15 K, which implies that α form nucleates easier than β form at low temperature. This work may be useful for the control and optimization of GSH crystallization process in industry.

Keywords

Glutathione Nucleation Induction Period Crystallization Classical Nucleation Theory

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