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Received June 10, 2013
Accepted July 24, 2013
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Precipitation characteristics of paclitaxel in solvent systems with different ion exchange resins
Department of Chemical Engineering, Kongju National University, Cheonan 330-717, Korea
Korean Journal of Chemical Engineering, October 2013, 30(10), 1954-1959(6), 10.1007/s11814-013-0136-2
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Abstract
We systematically examined the effect of the solvent system (methanol/water or acetone/pentane) on precipitation characteristics and mechanisms in the increased surface area precipitation (ISAP) with different ion exchange resins for the purification of paclitaxel. When Amberlite IRA 400Cl was added to increase the surface area, the acetone/pentane system was found to be more effective than the methanol/water system in terms of paclitaxel purity. The addition of surface area-increasing materials increased the yield in the methanol/water system, whereas it decreased the yield in the acetone/pentane system. Precipitates in the methanol/water system were needle-shaped or star-shaped, spreading from the central nucleus along the growing branches, while precipitates in the acetone/pentane system were disk shaped, branching out from around the nucleus. When Amberlite IRA 400Cl was added, it was possible to obtain smaller paclitaxel precipitates in the acetone/pentane system than in the methanol/water system.
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Kim JH, Kang IS, Choi HK, Hong SS, Lee HS, Biotechnol. Lett., 22(22), 1753 (2000)
Pyo SH, Kim MS, Cho JS, Song BK, Han BH, Choi HJ, J. Chem. Technol. Biotechnol., 79, 1162 (2005)
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Choi SW, Kwon HY, Kim WS, Kim JH, Colloids Surf. A., 201, 283 (2002)
