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In relation to this article, we declare that there is no conflict of interest.
Publication history
Received July 18, 2012
Accepted October 2, 2012
articles This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Dispersion stability of citrate- and PVP-AgNPs in biological media for cytotoxicity test

Department of Chemical Engineering, Kwangwoon University, Seoul 139-701, Korea 1School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Korea
korea1@kw.ac.kr
Korean Journal of Chemical Engineering, March 2013, 30(3), 671-674(4), 10.1007/s11814-012-0172-3
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Abstract

Silver nanoparticles (AgNPs) with antimicrobial property have been used for years in various applications, such as antibacterial coating and air/water purification to eliminate microorganisms. In recent years, a number of studies on the potential risk of nanomaterials in humans and the environment have appeared, and thus a large number of studies regarding the toxic effects of AgNPs on cells and micro-organisms have been reported. In in-vivo and invitro cytotoxicity tests, various biological media are used, and thus the dispersion stability of AgNPs in media is important to a successful toxicity test. Therefore, we investigated the dispersion stability of AgNPs in various biological media; PBS (phosphate buffered saline), FBS (fetal bovine serum), and de-ionized water (pH 2, 7, and 9) with and without photo-irradiation. Herein, citrate and PVP (polyvinylpyrrolidone) stabilized AgNPs were used as target materials. In short- and long-term stability tests, we found that PVP-AgNPs stabilized by steric hindrance have good dispersion_x000D_ stability in biological media, compared to citrate-AgNPs stabilized by electrostatic repulsion.

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