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Received June 18, 2013
Accepted October 4, 2013
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Effect of Scutellaria baicalensis extract on skin barrier function via peroxisome proliferator-activated receptor-α
R&D Center of Skin Science and Cosmetics, Enprani Co., Ltd., Incheon 400-103, Korea 1Department of Food Science and Industry, Jungwon University, Chungbuk 367-805, Korea
Korean Journal of Chemical Engineering, January 2014, 31(1), 104-108(5), 10.1007/s11814-013-0202-9
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Abstract
Scutellaria baicalensis extract (SBE) was investigated to determine its effects on the transactivation activity of peroxisome proliferator-activated receptors (PPAR)-responsive element (PPRE) and anti-oxidant activity for improvement of skin barrier function. The treatment with SBE resulted in a significant increase in the transactivation activity of PPRE such as PPAR-α and effect in anti-oxidant and anti-microbial activity. In addition, SBE promotes the expression of protein related to cornified envelope (CE) formation such as involucrin. Therefore, these results indicate that SBE can promote keratinocyte differentiation and restore skin barrier homeostasis, and is suggested to be an appropriate skin therapeutic agent for improving epidermal permeability barrier function.
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References
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Kuenzli S, Saurat JH, Br. J. Dermatol., 149(2), 229 (2003)
Dubrac S, Schmuth M, Dermatoendocrinol., 3, 23 (2011)
Hanley K, Jiang Y, He SS, Friedman M, Elias PM, Bikle DD, Williams ML, Feingold KR, J. Clin. Invest., 110, 368 (1998)
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Hanley K, Jiang Y, Crumrine D, Bass NM, Appel R, Elias PM, Williams ML, Feingold KR, J. Clin. Invest., 100(3), 705 (1997)
Hatano Y, Elias PM, Crumrine D, Feingold KR, Katagiri K, Fujiwara S, J. Invest. Dermatol., 131(9), 1845 (2011)
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Lam UDP, Hoang DN, Lee HB, Kim B, Lee JD, Shin JH, Kim EK, Korean J. Chem. Eng., 28(4), 1074 (2011)
