Articles & Issues

Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received May 30, 2013
Accepted October 4, 2013

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

All issues

Solvated behavior and crystal growth mechanism of erythromycin in aqueous acetone solution

Zhanzhong Wang^† Wenzhi Fang Yan Li

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China

wzz7698@tju.edu.cn

Korean Journal of Chemical Engineering, January 2014, 31(1), 120-124(5), 10.1007/s11814-013-0199-0

Download PDF

Abstract

The solubility of erythromycin acetone solvate and dihydrate was experimentally determined in aqueous acetone mixtures at different temperature. It has been demonstrated that solubility curves of the two solvates intersected at given solvent composition at various temperature, suggesting a transition behavior between two solvates. The induction period of acetone solvate at different supersaturation was measured by the laser monitoring observation technique. Based_x000D_ on classical homogeneous nucleation theory, the solid.liquid interfacial tension and surface entropy factor were calculated from the induction period data. From the surface entropy factor values calculated, together with surface morphology observation by the atomic force microscopy (AFM), the growth mechanism of erythromycin acetone solvate is consistent with continuous growth mode.

Keywords

Erythromycin Crystal Growth Mechanism Solvated Crystals Induction Time Transformation

References

Nangia A, Cryst. Growth Des., 6, 2 (2006)
Chopra D, Guru Row TN, Cryst. Growth Des., 7, 848 (2007)
Kitamura M, Cryst. Growth Des., 4, 1153 (2004)
Cindy G, Hezekiah KC, Ann VS, Rapid Commun. Mass Sp., 14, 878 (2000)
Yoshinobu F, Yomoaki F, Yuko Y, Chem. Pharm. Bull., 31, 4029 (1983)
Madrasa G, McCoy BJ, Chem. Eng. Sci., 59, 2573 (2004)
Kitamura M, Hironaka S, Cryst. Growth Des., 6, 1214 (2006)
Gregory AS, Joseph GS, Stowell HP, J. Pharm. Sci., 86, 1239 (1997)
Miroshnyk I, Khriachtchev L, Mirza S, Cryst. Growth Des., 6, 369 (2006)
Butler MN, Weber WJ, Environ. Sci. Technol., 39, 2301 (2005)
Graham AE, Thomas AV, Yang R, J. Org. Chem., 65, 2583 (2000)
Wang ZZ, Wang JK, Dang LP, Zhang MJ, Ind. Eng. Chem. Res., 46(6), 1851 (2007)
Bernardo A, Calmanovici CE, Miranda EA, Cryst. Growth Des., 4, 799 (2004)
Hao HX, Wang JK, Wang YL, J. Cryst. Growth, 274(3-4), 545 (2005)
Geng YL, Xu D, Wang XQ, Pan DY, Zhang GH, Yu GW, J. Cryst. Growth, 280(1-2), 266 (2005)
Lancia A, Musmarra D, Prisciandaro M, AIChE J., 45(2), 390 (1999)
Kitamura M, Nakamura K, J. Cryst. Growth, 236(4), 676 (2002)
Selvaraju K, Valluvan R, Kumararaman S, Mater. Lett., 60, 1549 (2006)
Davey RJ, Curr. Topics Mater. Sci., 8, 454 (1982)