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Received October 28, 2013
Accepted April 16, 2014
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Chrysanthemum zawadskii extract activates peroxisome proliferator-activated receptor-α and has an anti-inflammatory activity : Potential interest for the skin barrier function
Skin and Bio Research, Ellead Co., Ltd., Gyeonggi 463-824, Korea 1Department of Food Science and Industry, Jungwon University, Chungbuk 367-805, Korea
Korean Journal of Chemical Engineering, October 2014, 31(10), 1831-1838(8), 10.1007/s11814-014-0109-0
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Abstract
Chrysanthemum zawadskii extract (CZE) was investigated to determine its effects on the transactivation activity of peroxisome proliferator-activated receptors (PPAR)-responsive element (PPRE) and activity of anti-inflammatory for improvement of skin barrier function. The treatment with CZE resulted in a significant increase in the transactivation activity of PPRE such as PPAR-α and suppression in the TNF-α-, IL-6-induced NF-κB luciferase activity and NO production. In addition, CZE promotes the expression of protein related to cornified envelope (CE) formation_x000D_
such as involucrin. Therefore, these results indicate that CZE can restore skin barrier homeostasis and is suggested to be an appropriate skin therapeutic agent.
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References
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Wakita H, Takigawa M, J. Biol. Chem., 274, 37285 (1999)
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