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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received November 9, 2013
Accepted April 16, 2014

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Alginate microspheres incorporating poly(hydroxyethyl acrylate-co-coumaryl acrylate-co-2-ethylhexyl acrylate) : Effect of temperature and UV irradiation on FITC-dextran release

Jin-Chul Kim^†

College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja-2dong, Chunchon, Gangwon-do 200-701, Korea

jinkim@kangwon.ac.kr

Korean Journal of Chemical Engineering, October 2014, 31(10), 1903-1909(7), 10.1007/s11814-014-0111-6

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Abstract

Alginate microspheres incorporating poly(hydroxyethyl acrylate-co-coumaryl acrylate-co-2-ethylhexyl acrylate) (P(HEA-CA-EHA)) were prepared using the water droplets of W/O emulsion as a template. P(HEA-CAEHA) was prepared by a free radical reaction and the HEA/CA/EHA molar ratio was calculated to be 96.1 : 2.0 : 1.9 on the 1H NMR spectrum. The copolymer exhibited a lower critical solution temperature around 27 ℃ in distilled water. The microspheres were prepared by using O/W emulsion as a template and Ca2+ as a cross-linker for alginate. The resulting microspheres were subjected to UV (365 nm) irradiation for the cross-linkage of P(HEA-CA-EHA). The irradiation of UV (254 nm) to the UV (365 nm)-treated microsphere promoted the release of FITC-dextran (MW. 4,000), possibly due to the cleavage of the CA residue dimers. However, the temperature change had little effect on the release degree in the range of 21 ℃ to 37 ℃.

Keywords

Alginate P(HEA-CA-EHA) Emulsion Microsphere Release

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