We synthesized molecularly imprinted polymers (MIPs) which can selectively separate carbamazepine (CMZ) as a pharmaceutically active compound by using supercritical fluid technology in supercritical carbon dioxide (scCO2), and also evaluated the adsorption properties of the prepared CMZ imprinted polymers (CMZ-IPs). CMZIPs is prepared with methacrylic acid (MAA) as a functional monomer, CMZ as a template, and ethylene glycol dimethacrylate_x000D_ (EGDMA) as a crosslinking agent. The binding characteristics of CMZ-IPs are evaluated using equilibrium binding experiments. The adsorption ability in aqueous solution of CMZ-IPs was investigated by HPLC analysis, measuring the adsorbed amounts for the template and its structural analogue, the selectivity factor (α), and the imprintinginduced promotion of binding (IPB). The adsorption properties with the change of pH and temperature of aqueous solution_x000D_ were also examined. The results of the evaluation analysis indicate that the prepared CMZ-IPs have high selectivity (102, 94, 75 and 44 μmol/g) and separation abilities.

Molecularly Imprinted Polymers (MIPs) Carbamazepine Supercritical Fluid Carbon Dioxide Adsorption Properties Separation Technology

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