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Received July 31, 2013
Accepted October 30, 2013
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Enhanced skin delivery and characterization of rutin-loaded ethosomes
Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 139-743, Korea
snpark@seoultech.ac.kr
Korean Journal of Chemical Engineering, March 2014, 31(3), 485-489(5), 10.1007/s11814-013-0232-3
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Abstract
We formulated rutin-loaded ethosomes and compared their vesicle size, loading efficiency, stability, and elasticity. In addition, an in vitro skin penetration experiment was performed. The results of the study indicated that ethosomes loaded with 0.005-0.03% rutin were stable during the four-week study period. Among them, those loaded with 0.03% rutin showed a vesicle size (190.20±14.57 nm) and loading efficiency (73.77%±0.01%). Therefore, the in vitro skin penetration experiment was performed using 0.03% rutin-loaded ethosome. Compared to an ethanolic solution of rutin (44.16%), rutin-loaded liposome (37.80%), and a distilled water (DW) solution of rutin (18.31%), rutin-loaded ethosome (93.31 μg; 61.30%) was superior in delivering rutin. Therefore, we suggest that ethosome loaded with 0.03% rutin enhance the skin penetration of rutin and may be used as a drug delivery system for natural cosmetic materials such as flavonoids.
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Lim MS, Han SB, Kwon SS, Park MA, Park SN, J. Soc. Cosmet. Scientists Korea, 38(2), 147 (2012)
Park SN, Lee MH, Kim SJ, Yu ER, Biochem. Biophys. Res. Commun., 435(3), 361 (2013)
Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M, J. Control. Release, 65, 403 (2000)
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Dubey V, Mishra D, Dutta T, Nahar M, Saraf DK, Jain NK, J. Control. Release, 123, 148 (2007)
Fang YP, Tsai YH, Wu PC, Huang YB, Int. J. Pharm., 356, 144 (2008)
Paolino D, Lucania G, Mardente D, Alhaique F, Fresta M, J. Control. Release, 106, 99 (2005)
Fang YP, Huang YB, Wu PC, Tsai YH, Eur. J. Pharm. Biopharm., 73, 391 (2009)
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Jain S, Tiwary AK, Sapra B, Jain NK, AAPS PharmSciTech., 8, E1 (2007)
Jain S, Jain P, Jain NK, Drug Dev. Ind. Pharm., 29, 1013 (2003)
Park SN, Lee HJ, Kim HS, Park MA, Gu HA, Korean J. Chem. Eng., 30(3), 688 (2013)
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