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Received October 4, 2013
Accepted November 17, 2013
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Polyelectrolyte complexes of chitosan self-assembled with fucoidan: An optimum condition to prepare their nanoparticles and their characteristics
1Department of Chemical Engineering, College of Engineering, Daegu University, Kyungsan, Gyeongbuk 712-714, Korea 2Laboratory of Pharmaceutical Bio-nanomaterials, Daegu University, Kyungsan, Gyeongbuk 712-714, Korea
khlim@daegu.ac.kr
Korean Journal of Chemical Engineering, April 2014, 31(4), 664-675(12), 10.1007/s11814-013-0243-0
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Abstract
The preparation conditions for both a high yield without aggregation and a small mean-size of chitosanfucoidan nanoparticles were sought by a screening method, i.e., discarding the ones satisfying neither of both to prepare them by polyelectrolyte complexation with chitosan and fucoidan. The effect of the pH level of chitosan solution and the chitosan-fucoidan mass ratio was investigated on the following aspects: the turbidity and aggregation pattern of suspension, the yield of dried mass, electrostatic interaction, fucoidan loading efficiency, the particle size distribution and the morphology of the polyelectrolyte complex prepared by polyelectrolyte complexation between chitosan and fucoidan. The mean size of prepared nanoparticle ranges between 365-900 nm. The nanoparticles tended to grow as the pH of chitosan was increased up to 3.69, after which they became smaller. This pattern of growth is prominent as the mass ratio of chitosan and fucoidan decrease. The conditions of pH 5 and 1 : 1 chitosan-fucoidan mass ratio were suggested as ad hoc optimum conditions by the screening method to prepare chitosan-fucoidan nanoparticles for high yield, small size and good suspension stability. They were almost consistent with the optimum conditions for the maximum value of chitosan-fucoidan nanoparticles prepared per unit input mass, which were analyzed by response surface methodology (RSM).
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Chevolot L, Foucault A, Chaubet F, Kervarec N, Sinquin C, Fisher AM, Vidal CB, Carbohyd. Res., 319, 154 (1999)
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Chen Y, Mohanraj VJ, Parkin JE, Letters in Peptide Science, 10, 621 (2003)
Kim HJ, Lee HC, Oh JS, Shin BA, Oh CS, Park RD, Yang KS, Cho CS, J. Biomater. Sci. Polym. Edn., 10, 543 (1999)
Maciel JS, Silva DA, Paula HCB, Paula RCM, European Polymer Journal, 41, 2726 (2005)
Shu XZ, Zhu KJ, Int. J. Pharm., 133, 217 (2002)
Chang KLB, Lin J, Carbohyd. Polym., 43, 163 (2000)
Sarmento B, Martins S, Ribeiro A, Veiga F, Neufeld R, Ferreira D, Int. J. Pept. Res. Therap, 12, 131 (2006)
Agnihotri SA, Mallikarjuna NN, Aminabhavi TM, J. Control Release, 100, 5 (2004)
Gan Q, Wang T, Cochrane C, Mccarron P, Colloids Surf., B: Biointerfaces, 44, 65 (2005)
Yongmei X, Shufang X, Yumin D, Hua Z, Polym. Mater. Sci. Eng., 91, 404 (2004)
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Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ, Pharm. Res., 14, 1431 (1997)
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Ichikawa S, Iwamoto S, Biosci. Biotechnol. Biochem., 69, 1637 (2005)
Liu Z, Jiao Y, Liu F, Zhang Z, J. Biomed. Mater. Res. A., 83, 806 (2007)
Andersson M, Lofroth JE, Int. J. Pharm., 257, 305 (2003)
Mao HQ, Roy K, Troung-Le VL, Janes KA, Lin KY, Wang Y, August JT, Leong KW, J. Control Release, 70, 399 (2001)
Zheng Y, Wu Y, Yang W, Wang C, Fu S, Shen X, J. Pharm. Sci., 95, 181 (2006)
Lin YH, Chung CK, Chen CT, Liang HF, Chen SC, Sung HW, Biomacromolecules, 6(2), 1104 (2005)
MER Duarte, MA Cardoso, MD Noseda, AS Cerezo, Carbohyd. Res., 333, 281 (2001)
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Aleseyenko TV, Zhanayeva SY, Venediktova AA, Zvyagintseva TN, Kuznetsova TA, Besednova NN, Korolenko TA, Bull. Exp. Bio. Med., 143, 730 (2007)
Coombe DR, Parish CR, Ramshaw IA, Snowden JM, Int. J. Cancer, 39(1), 82 (1987)
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Boisson-Vidal C, Chaubet F, Chevolot L, Sinquin C, Theveniaux J, Millet J, Sternberg C, Mulloy B, Fischer AM, Drug Devel. Res., 51, 216 (2000)
McCaffrey TA, Falcone DJ, Borth W, Brayton CF, Weksler BB, Biochem. Biophys. Res. Commun., 184, 773 (1992)
Nasu T, Fukuda Y, Nagahira K, Kawashima H, Noguchi C, Nakanishi T, Immunol. Lett., 59, 47 (1997)
Berteau O, Mulloy B, Glycobiology, 13, 29 (2003)
Mourao PAS, Pereira MS, Trends Cardiovasc. Med., 9, 225 (1999)
Iqbal M, Flick-Smith H, McCauley JW, J. Gen. Virol., 81, 451 (2000)
Reis CP, Neufeld RJ, Ribeiro AJ, Veiga F, Nanomedicine: Nanotechnology, Biology, and Medicine, 2, 8 (2006)
Ranaldi G, Marigliano I, Vespigrani I, Perozzi G, Sambuy Y, J. Nutr. Biochem., 13, 157 (2002)
Yue ZG, Wei W, Lv PP, Yue H, Wang LY, Su ZG, Ma GH, Biomacromolecules, 12(7), 2440 (2011)
Lee EJ, Khan SA, Lim KH, World J. Eng. Issue Supplement, 541 (2009)
Murakami K, Aoki H, Nakamura S, Nakamura SH, Takikawa M, Hanzawan M, Kishimito S, Hattori H, Tanaka Y, Kiyosawa T, Sato Y, Ishihara M, Biomaterials, 31, 83 (2010)
Huang YC, Liu TJ, Acta Biomater., 8, 1048 (2012)
Huang YC, Lam UI, J. Chin. Chem. Soc., 58, 1 (2011)
Mitsumata T, Suemitsu Y, Fujii K, Fujii T, Taniguchi T, Koyama K, Polymer, 44(23), 7103 (2003)
Fredheim GE, Christensen BE, Biomacromolecules, 4(2), 232 (2003)
Tang DW, Yu SH, Ho YC, Mi FL, Kuo PL, Sung HW, Biomaterials, 31, 9320 (2010)
Sheng PX, Ting YP, Chen JP, Hong L, J. Colloid Interface Sci., 275(1), 131 (2004)
Yin YJ, Yao KD, Cheng GX, Ma JB, Polym. Int., 48, 429 (1999)
Santos JE, Dockal ER, Cavalheiro ER, Carbohyd. Polym., 60, 277 (2005)
Yanming D, Congyi XU, Jianwei W, Mian W, Yusong WU, Yonghong R, Science in China (Series B), 44, 216 (2001)
Nieman KG, Principles of Instrumental Analysis, 5, 410 (1998)
Yadav KSH, Satich CS, Shivakumar HG, Ind. J. Pharm. Sci., 69, 91 (2007)
Chao AC, Shyu SS, Lin YC, Mi FL, Bioresour. Technol., 91(2), 157 (2004)
Grant J, Blicker M, Piquette-Miller M, Allen C, J. Pharm. Sci., 94, 1512 (2005)
Zonggang C, Xiumei M, Fengling Q, Mater. Lett., 61, 3490 (2007)
Chevolot L, Foucault A, Chaubet F, Kervarec N, Sinquin C, Fisher AM, Vidal CB, Carbohyd. Res., 319, 154 (1999)
Lee JI, Jung HJ, J. Korean Chem. Soc., 49, 609 (2005)
Lee J, J. Pharm. Sci., 92, 2057 (2003)
