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Received August 10, 2013
Accepted December 19, 2013
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Synthesis, recognition and evaluation of molecularly imprinted polymer nanoparticle using miniemulsion polymerization for controlled release and analysis of risperidone in human plasma samples
Ebadullah Asadi
Saman Azodi-Deilami
Majid Abdouss†
Davood Kordestani1
Alireza Rahimi2
Somayeh Asadi3
Department of Chemistry, Amirkabir University of Technology, P. O. Box 15875-4413, Tehran, Iran 1Faculty of Chemistry, Department of Organic Chemistry, Razi University, Kermanshah, Iran 2Electrochemistry and Inhibitors Group, Environmental Protection Department, Research Institute of Petroleum Industry (RIPI), West Blvd of Azadi Sport Complex, Tehran, Iran 3Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
phdabdouss44@aut.ac.ir
Korean Journal of Chemical Engineering, June 2014, 31(6), 1028-1035(8), 10.1007/s11814-013-0287-1
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Abstract
We prepared high selective imprinted nanoparticle polymers by a miniemulsion polymerization technique, using risperidone as the template, MAA as the functional monomers, and TRIM as the cross-linker in acetonitrile as solvent. The morphology of the nanoparticles determined by scanning electron microscopy (SEM) images and drug release, binding properties and dynamic light scattering (DLS) of molecularly imprinted polymers (MIPs) were studied. Controlled release of risperidone from nanoparticles was investigated through in 1% wt sodium dodecyl sulfate aqueous solution and by measuring the absorbance by HPLC-UV. The results showed that the imprinted nanoparticles exhibited a higher binding level and slower release rate than non-imprinted nanoparticles, which contributed to interaction of risperidone with imprinted cavities within nanoparticles. Furthermore, the results from HPLC showed good precision (5% for 50.0 μg L^(-1)) and recoveries (between 86-91) using MIP from human plasma samples.
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References
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Azodi-Deilami S, Abdouss M, Hasani AR, Cent. Eur. J. Chem., 8, 861 (2010)
Javanbakht M, Eynollahi Fard S, Mohammadi A, Abdouss M, Ganjali MR, Norouzi P, Safaraliee L, Anal. Chim. Acta, 612, 65 (2008)
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Chen Wen, Han DK, Ahn KD, Kim JM, Macromol. Res., 10(2), 122 (2002)
Suedee R, Srichana T, Martin G, J. Controlled Release, 66, 135 (2000)
Sambe H, Hoshina K, Moadel R, Wainer W, Haginaka J, J. Chromatogr. A, 1134, 88 (2006)
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Ding X, Heiden PA, Macromol. Mater. Eng., DOI:10.1 002/mame.201300160 (2013)
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Yan HY, Row KH, Int. J. Mol. Sci., 7(5-6), 155 (2006)
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Allender CJ, Richardson C, Woodhouse B, Heard CM, Brain KR, Int. J. Pharm., 195, 39 (2000)
Ju JY, Shin CS, Whitcombe MJ, Vulfson EN, Biotechnol. Bioeng., 64(2), 232 (1999)
Alvarez-Lorenzo C, Concheiro A, Biotech. Ann. Rev., 12, 225 (2006)
Hiratani H, Alvarez-Lorenzo C, J. Controlled Release, 83, 223 (2002)
Alvarez-Lorenzo C, Concheiro A, J. Chromatogr., B, 804, 231 (2004)
Alvarez-Lorenzo C, Yanez F, Barreiro-Iglesias R, Concheiro A, J. Controlled Release, 113, 236 (2006)
Sellergren B, Allender CJ, Adv. Drug Deliv. Rev., 57, 1733 (2005)
Turchan M, Jara-Ulloa P, Bollo S, Nunez-Vergara LJ, Squella JA, Alvarez-Lueje A, Talanta, 73, 913 (2007)
Jiang J, Song K, Chen Z, Zhou Q, Tang Y, Gu F, Zou X, Xu Z, J. Chromatogr. A, 1218, 3763 (2011)
Jiang LH, Sun GQ, Zhou ZH, Sun SG, Wang Q, Yan SY, Li HQ, Tian J, Guo JS, Zhou B, Xin Q, J. Phys. Chem. B, 109(18), 8774 (2005)
Huang C, Hu B, Spectrochim. Acta B, 63, 437 (2008)
Aruna I, Kruis FE, Kundu S, Muhler M, Theissmann R, Spasova M, J. Appl. Phys., 105, 064312 (2009)
Nilsson C, Nilsson S, Electrophoresis, 27(1), 76 (2006)
Gaumet M, Vargas A, Gurny R, Delie F, Eur. J. Pharm. Biopharm., 69, 1 (2008)
Martin P, Jones GR, Stringer F, Wilson ID, Analyst., 128, 345 (2003)
Mullet WM, Walles M, Levsen K, Borlak J, Pawliszyn J, J. Chromatogr. B., 801, 297 (2004)
