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Received January 12, 2014
Accepted June 12, 2014
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Studies on encapsulation of Rifampicin and its release from chitosan-dextran sulfate capsules
Department of Chemical Engineering, National Institute of Technology Durgapur, India 1Department of Chemistry, Sultan Quaboos University, Sultanate of Oman 2Caledonian College of Engineering, Sultanate of Oman
gdmdevi@gmail.com
Korean Journal of Chemical Engineering, January 2015, 32(1), 118-124(7), 10.1007/s11814-014-0161-9
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Abstract
Biodegradable capsules of size around 350 nm were prepared by layer-by-layer (L-b-L) assembly of oppositely charged chitosan and dextran sulfate on silica particles and the subsequent removal of template. The resulting capsules were loaded with rifampicin, an anti-tuberculosis drug under modest conditions, as demonstrated by scanning electron microscopy (SEM). Maximum encapsulation of rifampicin was found to be about 82 μg at 25 ℃ and pH of_x000D_
3. Release studies were done in-vitro mode by semiautomatic release protocol, with different pH solutions in water and phosphate buffered saline (PBS). The microcapsules exhibited a slow and sustained release over 72 hours and maximum release was obtained at a pH of 1.2 in water and a pH of 7.4 in PBS. The size of silica particle was analyzed by dynamic light scattering method. Scanning electron microscopy (SEM) measurements showed the surface morphology of the hollow capsules. UV spectroscopy was employed to monitor the drug release processes in both solutions. The kinetics of drug release mechanism was studied using Ritger-Peppas and Higuchi models.
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References
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Muzzarelli RAA, Cell Mol. Life Sci., 53, 131 (1997)
Koga D, Chen R, Chen HC, Adv. Chitin Sci., 3, 16 (1998)
Junginger HE, Verhoef JC, PSTT, 1, 370 (1998)
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Ueno H, Mori T, Fujinaga T, Adv. Drug Deliv. Rev., 52, 105 (2001)
Felt O, Carrel A, Baehni P, Buri P, Gurny R, J. Ocul. Pharmacol. Ther., 16, 261 (2000)
Caruso F, Yang WJ, Trau D, Renneberg R, Langmuir, 16(23), 8932 (2000)
Antipov AA, Sukhorukov GB, Donath E, Mohwald H, J. Phys. Chem. B, 105(12), 2281 (2001)
Liu XF, Guan YL, Yang DZ, Li Z, De Yao K, J. Appl. Polym. Sci., 79(7), 1324 (2001)
Schatz C, Domard A, Viton C, Pichot C, Delair T, Biomacromolecules, 5(5), 1882 (2004)
Bogush MA, Tracy CF, Zukoski IV CF, J. Non-Crystalline Solids, 104, 95 (1988)
Stober W, Fink A, Boahn E, J. Coll. Int. Science, 26, 62 (1968)
Liang ZP, Liang CY, Sun QL, Tong Z, Prog. Chem., 16, 485 (2004)
Voigt A, Lichtenfeld H, Sukhorukov GB, Zastrow H, Donath E, Baumler H, Mohwald H, Ind. Eng. Chem. Res., 38(10), 4037 (1999)
Peppas NA, Pharm. Acta Helv., 60, 110 (1985)
Higuchi T, J. Pharm. Sci., 51, 1145 (1963)
Mao Z, Ma L, Gao C, J. Cont. Release., 104, 193 (2005)
Devi MG, Dutta S, Al Hinai AT, Feroz S, Indian Chem. Eng., 45, 1 (2013)
