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Received September 1, 2014
Accepted January 6, 2015
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Novel double-walled microspheres based on chitosan, sodium cellulose sulfate and sodium tripolyphosphate: Preparation, characterization and in vitro release study
1College of Sciences, Nanjing University of Technology, Nanjing 211816, P. R. China 2Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China 3College of Food Science and Light Industry, Nanjing University of Technology, Nanjing 211816, P. R. China
jinagling@njtech.edu.cn
Korean Journal of Chemical Engineering, March 2015, 32(3), 369-372(4), 10.1007/s11814-015-0007-0
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Abstract
A novel double-walled microsphere composed of chitosan, sodium cellulose sulfate (NaCS) and sodium tripolyphosphate (TPP) was prepared. TPP was used as ionic crosslinker. The morphology of the microspheres was observed by microscope and SEM, and the results showed that the double-walled microsphere was smooth outside, with rough interior surface. FTIR spectra analysis was performed to investigate the PEC formation among chitosan, NaCS, and TPP. In vitro release studies of BSA showed that the double-walled microspheres had regular and sustainable release profiles in simulated colonic fluid (SCF). Our results indicated that the double-walled microspheres prepared could be used as a candidate protein drug carrier for the colon.
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