Articles & Issues
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
-
Received March 26, 2014
Accepted August 12, 2014
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
All issues
Formation of stable hydrocarbon oil-in-water nanoemulsions by phase inversion composition method at elevated temperature
Department of Fine Chemistry, Cosmetic R&D Center, College of Energy and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 137-743, Korea 1College of Medical Science, Jeonju University, 303, Cheonjam-ro, Wansan-gu, Jeonju 560-759, Korea
wgcho@jj.ac.kr
Korean Journal of Chemical Engineering, March 2015, 32(3), 540-546(7), 10.1007/s11814-014-0234-9
Download PDF
Abstract
Stable hydrocarbon oil (hexadecane, C16)/nonionic surfactant (HCO-60, Span 80)/water system oil-inwater nanoemulsions were prepared by the phase inversion composition method at elevated temperature. To minimize droplet size, the composition ratio for stable nanoemulsions, we experimented by changing the HLB value, oil/surfactant ratio, and droplet volume fraction. When the HLBmix value 11, the nanoemulsions show a minimal sample droplet size of 360.3 nm. By varying the oil/surfactant ratio from 0.6 to 1.4, we found the optimum oil/surfactant ratio to be_x000D_
approximately 0.6, which corresponds to the minimum droplet size of 71.8 nm. We also varied the droplet volume fraction; when the droplet volume fraction is 0.06, the droplet size is very small. For the emulsion with the minimal droplet size, the polydispersity index is less than 0.3, which reflects a good monodispersity of the nanoemulsion. Viscosity and electrical conductivity measurements were carried out for determining the internal structure of the bicontinuous_x000D_
phase during the emulsification. When the water content ranges from 4 to 6 w/w%, the systems may have a bicontinuous or lamellar phase. Oil-in-water nanoemulsion stability assessment was performed by observing the droplet size as a function of storage time; we did not observe any change in droplet size over the course of a month.
Keywords
References
McClements DJ, Decker EA, Weiss J, J. Food Sci., 72, 109 (2007)
McClements DJ, Soft Matter, 48, 2279 (2011)
Aubrun OS, Simonnet JT, Alloret FL, Adv. Colloid Interface Sci., 108, 145 (2004)
Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ, Curr. Opin. Colloid Interface Sci., 10, 102 (2005)
Tadros T, Izquierdo P, Esquena J, Solans C, Adv. Colloid Interface Sci., 108, 303 (2004)
Sadurn N, Solans C, Azemara N, Garcia-Celma MJ, Eur. J. Pharm. Sci., 26, 438 (2005)
Atrux-Tallau N, Delmas T, Han SH, Kim JW, Bibette J, Int. J. Cosmet. Sci., 35, 310 (2013)
Constantinides PP, Pharm. Res., 12, 1561 (1995)
Yu LJ, Li C, Xu J, Hao JC, Sun DJ, Langmuir, 28(41), 14547 (2012)
Jafari SM, He Y, Bhandari B, Food Res. Int., 40, 862 (2007)
Kentish S, Wooster TJ, Ashokkumar M, Balachandran S, Mawson R, Simons L, Innovative Food Sci. Emerg. Technol., 9, 170 (2008)
Rao J, McClements DJ, J. Agric. Food Chem., 58, 7059 (2010)
Nakabayashi K, Amemiya F, Fuchigami T, Machida K, Takeda S, Tamamitsu K, Atobe M, Chem. Commun., 47, 5765 (2011)
Graves S, Meleson K, Wilking J, Lin MY, Mason TG, J. Chem. Phys., 122, 134703 (2005)
Roger K, Cabane B, Olsson U, Langmuir, 27(2), 604 (2011)
Sole I, Maestro A, Gonzalez C, Solans C, Gutierrez JM, Langmuir, 22(20), 8326 (2006)
Dai L, Li W, Hou X, Colloids Surf., A, 125, 27 (1997)
Sagitani H, J. of Korean Oil Chemists' Soc., 58, 738 (1981)
Solans C, Sole I, Curr. Opin. Colloid Interface Sci., 17, 246 (2012)
Gutierrez JM, Gonzalez C, Maestro A, Sole I, Pey CM, Nolla J, Curr. Opin. Colloid Interface Sci., 13, 245 (2008)
Forgiarini A, Esquena J, Gonzalez C, Solans C, Langmuir, 17(7), 2076 (2001)
Antonya T, Saxenaa A, Royb KB, Bohidara HB, J. Biochem. Biophys. Methods, 36, 75 (1998)
Pey CM, Maestro A, Sole I, Gonzalez C, Solans C, Gutierrez JM, Colloids Surf., A, 288, 144 (2006)
Liu WR, Sun DJ, Li CF, Liu Q, Xu H, J. Colloid Interface Sci., 303(2), 557 (2006)
Fernandez P, Andre V, Rieger J, Kuhnle A, Colloids Surf., A, 251, 53 (2004)
Nazarzadeh E, Anthonypillai T, Sajjadi S, J. Colloid Interface Sci., 397, 154 (2013)
Mayer S, Weiss J, McClements DJ, J. Colloid Interface Sci., 402, 122 (2013)
Wilking JN, Chang CB, Fryd MM, Porcar L, Mason TG, Langmuir, 27(9), 5204 (2011)
Malheiro AR, Varanda LC, Perez J, Villullas HM, Langmuir, 23(22), 11015 (2007)
Lopes LB, Vandewall H, Li HT, Venugopal V, Li HK, Naydin S, Hosmer J, Levendusky M, Zheng H, Vitoria M, Bentley LB, Levin R, Hass MA, J. Pharm. Sci., 99, 1346 (2010)
Forgiarini A, Esquena J, Gonzalez C, Solans C, Langmuir, 17(7), 2076 (2001)
Izquierdo P, Esquena J, Tadros TF, Dederen C, Garcia MJ, Azemar N, Solans C, Langmuir, 18(1), 26 (2002)
Deminiere B, In Modern Aspects of Emulsion Science, Binks BP Ed., The Royal Society of Chemistry, Cambridge (1998)
Lifshitz IM, Slezov VV, J. Phys. Chem. Solids, 19, 35 (1961)
Wagner C, Zeit. Electrochem., 65, 581 (1961)
Morales D, Gutierrez JM, Garcia-Celma MJ, Solans YC, Langmuir, 19(18), 7196 (2003)
Yang HJ, Cho WG, Park SN, J. Ind. Eng. Chem., 15(3), 331 (2009)
McClements DJ, Soft Matter, 48, 2279 (2011)
Aubrun OS, Simonnet JT, Alloret FL, Adv. Colloid Interface Sci., 108, 145 (2004)
Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ, Curr. Opin. Colloid Interface Sci., 10, 102 (2005)
Tadros T, Izquierdo P, Esquena J, Solans C, Adv. Colloid Interface Sci., 108, 303 (2004)
Sadurn N, Solans C, Azemara N, Garcia-Celma MJ, Eur. J. Pharm. Sci., 26, 438 (2005)
Atrux-Tallau N, Delmas T, Han SH, Kim JW, Bibette J, Int. J. Cosmet. Sci., 35, 310 (2013)
Constantinides PP, Pharm. Res., 12, 1561 (1995)
Yu LJ, Li C, Xu J, Hao JC, Sun DJ, Langmuir, 28(41), 14547 (2012)
Jafari SM, He Y, Bhandari B, Food Res. Int., 40, 862 (2007)
Kentish S, Wooster TJ, Ashokkumar M, Balachandran S, Mawson R, Simons L, Innovative Food Sci. Emerg. Technol., 9, 170 (2008)
Rao J, McClements DJ, J. Agric. Food Chem., 58, 7059 (2010)
Nakabayashi K, Amemiya F, Fuchigami T, Machida K, Takeda S, Tamamitsu K, Atobe M, Chem. Commun., 47, 5765 (2011)
Graves S, Meleson K, Wilking J, Lin MY, Mason TG, J. Chem. Phys., 122, 134703 (2005)
Roger K, Cabane B, Olsson U, Langmuir, 27(2), 604 (2011)
Sole I, Maestro A, Gonzalez C, Solans C, Gutierrez JM, Langmuir, 22(20), 8326 (2006)
Dai L, Li W, Hou X, Colloids Surf., A, 125, 27 (1997)
Sagitani H, J. of Korean Oil Chemists' Soc., 58, 738 (1981)
Solans C, Sole I, Curr. Opin. Colloid Interface Sci., 17, 246 (2012)
Gutierrez JM, Gonzalez C, Maestro A, Sole I, Pey CM, Nolla J, Curr. Opin. Colloid Interface Sci., 13, 245 (2008)
Forgiarini A, Esquena J, Gonzalez C, Solans C, Langmuir, 17(7), 2076 (2001)
Antonya T, Saxenaa A, Royb KB, Bohidara HB, J. Biochem. Biophys. Methods, 36, 75 (1998)
Pey CM, Maestro A, Sole I, Gonzalez C, Solans C, Gutierrez JM, Colloids Surf., A, 288, 144 (2006)
Liu WR, Sun DJ, Li CF, Liu Q, Xu H, J. Colloid Interface Sci., 303(2), 557 (2006)
Fernandez P, Andre V, Rieger J, Kuhnle A, Colloids Surf., A, 251, 53 (2004)
Nazarzadeh E, Anthonypillai T, Sajjadi S, J. Colloid Interface Sci., 397, 154 (2013)
Mayer S, Weiss J, McClements DJ, J. Colloid Interface Sci., 402, 122 (2013)
Wilking JN, Chang CB, Fryd MM, Porcar L, Mason TG, Langmuir, 27(9), 5204 (2011)
Malheiro AR, Varanda LC, Perez J, Villullas HM, Langmuir, 23(22), 11015 (2007)
Lopes LB, Vandewall H, Li HT, Venugopal V, Li HK, Naydin S, Hosmer J, Levendusky M, Zheng H, Vitoria M, Bentley LB, Levin R, Hass MA, J. Pharm. Sci., 99, 1346 (2010)
Forgiarini A, Esquena J, Gonzalez C, Solans C, Langmuir, 17(7), 2076 (2001)
Izquierdo P, Esquena J, Tadros TF, Dederen C, Garcia MJ, Azemar N, Solans C, Langmuir, 18(1), 26 (2002)
Deminiere B, In Modern Aspects of Emulsion Science, Binks BP Ed., The Royal Society of Chemistry, Cambridge (1998)
Lifshitz IM, Slezov VV, J. Phys. Chem. Solids, 19, 35 (1961)
Wagner C, Zeit. Electrochem., 65, 581 (1961)
Morales D, Gutierrez JM, Garcia-Celma MJ, Solans YC, Langmuir, 19(18), 7196 (2003)
Yang HJ, Cho WG, Park SN, J. Ind. Eng. Chem., 15(3), 331 (2009)
