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Received January 11, 2015
Accepted April 8, 2015
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A simultaneous microwave-assisted extraction and adsorbent treatment process under acidic conditions for recovery and separation of paclitaxel from plant cell cultures
Department of Chemical Engineering, Kongju National University, Cheonan 330-717, Korea
Korean Journal of Chemical Engineering, June 2015, 32(6), 1023-1028(6), 10.1007/s11814-015-0075-1
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Abstract
We have developed a simultaneous microwave-assisted extraction and adsorbent treatment process under acidic conditions to increase the recovery and separation efficiency of the anticancer agent paclitaxel from plant cell culture. The simultaneous process under the conditions of extracting solution (90% aqueous methanol), pH 2.2, extraction time, 6min, ratio of extracting solution to biomass, 1 : 1 (v/w), extraction temperature, 40 oC, adsorbent type, sylopute, and ratio of adsorbent to biomass, 0.08 : 1 (w/w), facilitated 1.97-fold higher recovery of paclitaxel in a shorter extraction time than the conventional solvent extraction process. In addition, biomass-derived tar compounds were successfully removed by the simultaneous process alone (average removal >97%). Using the simultaneous process, the paclitaxel extraction efficiency was improved, biomass-derived tar compounds were removed, and the purification process was simplified at the same time.
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References
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Baloglu E, Kingston DGI, J. Nat. Prod., 62, 1068 (1999)
Zhang B, Yang RY, Liu CZ, Sep. Purif. Technol., 62(2), 480 (2008)
Kim WK, Chae HJ, Kim JH, Biotechnol. Bioproc. Eng., 15, 481 (2010)
Kwon JH, Choi YH, Chung HW, Lee GD, Int. J. Food Sci. Technol., 41, 67 (2006)
Fulzele DP, Satdive RK, J. Chro, 1063, 9 (2005)
Chen F, Mo K, Liu Z, Yang F, Hou K, Li S, Zu Y, Yang L, Molecules, 19, 9689 (2014)
Shu YY, Ko MY, Chang YS, Microchem J., 74, 131 (2003)
Pan X, Liu H, Jia G, Shu YY, Biochem. Eng. J., 5, 173 (2000)
Pan XJ, Niu GG, Liu HZ, Chem. Eng. Process., 42(2), 129 (2003)
Hyun JE, Kim JH, Korean J. Biotechnol. Bioeng., 23, 281 (2008)
Lee JY, Kim JH, Sep. Purif. Technol., 80(2), 240 (2011)
Kim GJ, Kim JH, Process Biochem., In Press (2014). (2014)
Choi HK, Adams TL, Stahlhut RW, Kim SI, Yun JH, Song BK, Kim JH, Song JS, Hong SS, Lee HS, US Patent, 5,871,979 (1999). (1999)
Jeon KY, Kim JH, Korean J. Biotechnol. Bioeng., 23, 557 (2008)
Kim GJ, Park GY, Kim JH, Korean J. Microbiol. Biotechnol., 41, 272 (2013)
Jeon YL, Kim JH, Korean J. Chem. Eng., 30(10), 1954 (2013)
Oh HJ, Jang HR, Jung KY, Kim JH, Process Biochem., 47, 331 (2012)
Park GY, Kim GJ, Kim JH, J. Ind. Eng. Chem., 21(1), 151 (2015)
Chen Y, Xie MY, Gong XF, J. Food Eng., 81(1), 162 (2007)
Criado MR, Torre SPD, Pereiro IR, Torrijos RC, J. Chromatogr. A, 1024, 155 (2004)
Gfrerer M, Lankmayr E, Anal. Chim. Acta, 533, 203 (2005)
