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Received November 1, 2015
Accepted January 6, 2016
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Antihyperglycemic and antioxidant activities of polysaccharide produced from Pleurotus ferulae in streptozotocin-induced diabetic rats
Dubok Choi1 2
YuLan Piao3
Sun-Jong Yu3
Yeon-Woong Lee3
Dong-Hoon Lim4
Young-Cheol Chang5
Sang-Shin Park6
Myung-Koo Lee1 7
Wol-Suk Cha3
Don-Sang You8
Hoon Cho3†
1Department of Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju 28644, Korea 2Biotechnology Laboratory, B-K Company Ltd., Jeonbuk 54008, Korea 3Department of Biochemical Polymer Science & Engineering, Chosun University, Gwangju 61452, Korea 4Department of Urology, School of Medicine, Chosun University, Gwangju 61452, Korea 5Biosystem Course, Division of Applied Sciences, Muroran Institute of Technology, 27-1 Mizumoto, Muroran 050-8585, Japan 6Department of Biotechnology, Dongguk University, Gyeongju 38066, Korea 7, Korea 8Leaders in Industry-University Cooperation Foundation, Chosun University, Gwangju 61452, Korea
hcho@chosun.ac.kr
Korean Journal of Chemical Engineering, June 2016, 33(6), 1872-1882(11), 10.1007/s11814-016-0007-8
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Abstract
We investigated the antihyperglycemic and antioxidant activities of polysaccharides produced from Pleurotus ferulae mutant in streptozotocin-induced diabetic rats. Blood glucose level in the STZ-induced diabetic rat administered the extract polysaccharides, 250mg/kg b·w/d (EPSG) was 196.97mg/dL, approximately 54.12% less compared to that of the STZ-induced diabetic rats administered 0.9% NaCl solution (NCG). The insulin level in the EPSG was approximately 1.64-fold higher than that in the NCG. HDL and LDL cholesterol levels in the EPSG were 29.15mg/L and 20.35mg/dL, respectively, representing an approximate increase of 69.18% and decrease of 38.52%, respectively. The activities of aspartate aminotransferase (AST) and alanine transferase (ALT) in the EPSG decreased approximately by 49.27 and 50.43%, respectively, while the alkaline phosphatase (ALP) activity decreased by 34.25%, relative to the NCG. Antioxidant activities in the NCG decreased relative to the normal group. In contrast, for EPSG, these values increased relative to the NCG. The malondialdehyde level in the EPSG was 12.95mmol/mg protein, which was approximately 70.64% of that in the NCG. These results suggest that the polysaccharides of Pleurotus ferulae mutant could be developed as potential antidiabetic agents or functional foods for people with a high risk of diabetes mellitus.
Keywords
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Hong KY, Kim BY, Kim HK, Korean J. Food Sci. Technol., 36, 563 (2004)
Rho JY, Park SD, J. Microbiol., 49, 191 (2013)
Choi DB, Kang SH, Song YH, Kwun KH, Jeong KJ, Cha WS, J. Microbiol. Biotechnol., 15, 368 (2005)
Choi DB, Cha WS, Kang SH, Biotechnol. Bioeng., 9, 356 (2004)
Kim BH, Choi DB, Piao YL, Park SS, Lee MK, Cha WS, Chang YC, Cho H, Korean J. Chem. Eng., 29(10), 1393 (2012)
Lo TC, Chang CA, Chiuc K, Tsayd PK, Jena JF, Carbohydr. Polym., 86, 320 (2011)
Lee SI, Kim JS, Oh SH, Park KY, Lee HG, Kim SD, J. Med. Food, 11, 518 (2008)
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Hu X, Yin PH, Zhao L, Yu Qm, Biotechnol. Bioeng., 20, 58 (2015)
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Kim MY, Park MH, Kim GH, J. Kor. Nutr., 30, 743 (1997)
Yuan Z, He P, Cui J, Takeuchi H, Bisci. Biotech. Biochem., 62, 1898 (1998)
Park HR, Cho JS, J. Nat. Sci., 25, 43 (2006)
Kalaiarasi P, Pugalendi KV, Eur. J. Pharmcol., 606, 269 (2009)
Yang BK, Jeong SC, Lee HL, Sohn DH, Song CH, Arch. Pharm. Res., 29, 73 (2006)
Kim DH, Yang BK, Jeong SC, Park JB, Cho SP, Das S, Yun JW, Song CH, Biotechnol. Lett., 23(7), 513 (2001)
Yang BK, Kim DK, Jeong SC, Das S, Choi YS, Shin JS, Lee SC, Song CH, Biosci. Biotechnol. Biochem., 66, 937 (2002)
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Zhang HN, He JH, Yuan L, Lin JB, Life Sci., 73, 2307 (2003)
Zang HN, Yuan ZB, Acta. Pharmacol. Sin., 25, 190 (2004)
Cha JY, Jeon BS, Park JW, Shin GC, Kim BK, Kim HK, Cho YS, J. Life Sci., 14, 676 (2004)
Abrahamson MJ, Arch. Inter. Med., 164, 486 (2004)
Ceriello A, Davidson J, Hanefeld M, Leiter L, Monnier L, Owens D, Tajima N, Tuomilehto J, Nutr. Metab. Cardiovasc. Dis., 16, 453 (2006)
Inoue I, Takahashi K, Noji S, Awata T, Negishi K, Diabetes Res. Clin. Pract., 36, 143 (2005)
Dennis JW, Laferte S, Waghorne C, Breitman ML, Kergel RS, Science, 236, 582 (1987)
Wang Y, Yang Z, Wie X, Int. J. Biol. Macromol., 47, 534 (2010)
Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EG, Swapna S, Ramesh B, Rao CA, Food Chem. Toxicol., 48, 1078 (2010)
Mori K, Kobayashi C, Tomita T, Inatomi S, Ikeda M, Nutr. Res., 28, 335 (2008)
Kiho T, Kochi M, Usui S, Hirano K, Aizawa K, Inakurma T, Inter. J. Med. Mush., 4, 291 (2002)
Ashry FE, Mahmoud MF, Maraghy NN, Ahmed AF, Food Chem. Toxicol., 50, 1159 (2011)
Gao J, Lian ZQ, Zhu P, Zhu HB, Yao Xue Xue Bao., 46, 669 (2011)
Kiho T, Yamane A, Hui J, Usui S, Ukai S, Biol. Pharm. Bull., 19, 294 (1996)
Taskinen MR, Diabetologia., 46, 733 (2003)
Brown WV, Clark L, Falko JM, Guyton JR, Rees TJ, Schonfeld G, Lopes-Virella MF, J. Clin. Lipidol., 2, 335 (2008)
Proctor SD, Mamo JC, Eur. J. Clin. Invest., 28, 497 (1998)
Stamler J, Vaccaro O, Neaton JD, Wentworth D, Diabetes Care., 16, 434 (1993)
Kim SH, Hyun SH, Choung SY, J. Ethnopharmacol., 104, 119 (2006)
Jasmine R, Daisy P, Int. J. Biol. Chem., 1, 117 (2007)
Jose N, Ajith TA, Jananrdhanan KK, Int. J. Med. Mush., 4, 59 (2002)
Leonid EF, Phillpson LH, Diabetes, 53, 1942 (2004)
Kaya M, Baran T, Asan-Ozusaglam M, Cakmak YS, Tozak KO, Mol A, Mentes A, Sezen G, Biotechnol. Biopro. Eng., 20, 168 (2015)
Hong SM, Choi JH, Jo SJ, Song SK, Lee JM, Kusakabe TH, Biotechnol. Biopro. Eng., 20, 515 (2015)
