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Received April 1, 2016
Accepted April 22, 2016
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems
Center of Applied Microfluidic Chemistry, Department of Chemical Engineering, POSTECH (Pohang University of Science and Technology), Pohang 37673, Korea
dpkim@postech.ac.kr
Korean Journal of Chemical Engineering, August 2016, 33(8), 2253-2267(15), 10.1007/s11814-016-0114-6
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Abstract
The development and enlargement of toxic and hazardous chemicals are severely limited by health and safety concerns. We summarize studies on fully integrated micro-chemical systems and total processes to reduce accidental exposure to various regents that are toxic, explosive, or carcinogenic, which significantly improved the safety of work involving risky compounds. This review covers the leak-free continuous-flow processes of hazardous chemicals in fully integrated microfluidic systems, specially denoted as micro-total envelope systems (μ-TESs), that are conducting a serial process of the generation of hazardous reagents, in-situ purification and separation, subsequent reaction, and product isolation with improved efficiencies. These attempts suggest safe and efficient tools and processes of useful but hazardous chemicals for researchers and manufacturing workers in the field of pharmaceutic discovery, natural products, biology as well as materials synthesis.
Keywords
References
Wirth T, Microreactors in Organic Synthesis and Catalysis, Wiley-VCH (2008).
Whitesides GM, Nature, 442, 368 (2006)
Frost CG, Mutton L, Green Chem., 12, 1687 (2010)
Marre S, Jensen KF, Chem. Soc. Rev., 39, 1183 (2010)
Kockmann N, Roberge DM, Chem. Eng. Technol., 32(11), 1682 (2009)
Gutmann B, Cantillo D, Kappe CO, Angew. Chem.-Int. Edit., 54, 6688 (2015)
Mallia CJ, Baxendale IR, Org. Process. Res. Dev., 20, 327 (2016)
Porta R, Benaglia M, Puglisi A, Org. Process. Res. Dev., 20, 2 (2016)
Webb D, Jamison TF, Chem. Sci., 1, 675 (2010)
Wiles C, Watts P, Green Chem., 14, 38 (2012)
Deadman BJ, Collins SG, Maguire AR, Chem.-Eur. J., 21, 2298 (2015)
Muller STR, Wirth T, ChemSusChem, 8, 245 (2015)
Amii H, Nagaki A, Yoshida JI, Beilstein J. Org. Chem., 9, 2793 (2013)
Brzozowski M, O’Brien M, Ley SV, Polyzos A, Acc. Chem. Res., 48, 349 (2015)
Oger N, Le Grognec E, Felpin FX, Org. Chem. Front., 2, 590 (2015)
Newman SG, Jensen KF, Green Chem., 15, 1456 (2013)
McQuade DT, Seeberger PH, J. Org. Chem., 78, 6384 (2013)
Gemoets HPL, Su Y, Shang M, Hessel V, Luque R, Noel T, Chem. Soc. Rev., 45, 83 (2016)
Cossar PJ, Hizartzidis L, Simone MI, McCluskey A, Gordon CP, Org. Biomol. Chem., 13, 7119 (2015)
Singh AK, Ko DH, Vishwakarma NK, Jang S, Min KI, Kim DP, Nat. Commun., 7 (2016)
Maurya RA, Park CP, Lee JH, Kim DP, Angew. Chem.-Int. Edit., 50, 5952 (2011)
Mastronardi F, Gutmann B, Kappe CO, Org. Lett., 15, 5590 (2013)
O’Brien M, Baxendale IR, Ley SV, Org. Lett., 12, 1596 (2010)
Pinho VD, Gutmann B, Miranda LSM, de Souza ROMA, Kappe CO, J. Org. Chem., 79, 1555 (2014)
Pinho VD, Gutmann B, Kappe CO, RSC Adv., 4, 37419 (2014)
Rossi E, Woehl P, Maggini M, Org. Process. Res. Dev., 16, 1146 (2012)
Maas G, Angew. Chem.-Int. Edit., 48, 8186 (2009)
Maurya RA, Min KI, Kim DP, Green Chem., 16, 116 (2014)
Bartrum HE, Blakemore DC, Moody CJ, Hayes CJ, J. Org. Chem., 75, 8674 (2010)
Martin LJ, Marzinzik AL, Ley SV, Baxendale IR, Org. Lett., 13, 320 (2011)
Bailey PS, Chem. Rev., 58, 925 (1958)
Bailey PS, Ozonolysis in Organic Chemistry, Academic Press (1978).
Bunnelle WH, Chem. Rev., 91, 335 (1991)
Zvereva TI, Kasradze VG, Kazakova OB, Kukovinets OS, Russ. J. Org. Chem., 46, 1431 (2010)
Urben LBPG, Bretherick’s Handbook of Reactive Chemical Hazards, 7th Ed., Oxford (1990).
Caron P, Dugger RW, Ruggeri SG, Ragan JA, Ripin DHB, Chem. Rev., 106(7), 2943 (2006)
Wada Y, Schmidt MA, Jensen KF, Ind. Eng. Chem. Res., 45(24), 8036 (2006)
Hubner S, Bentrup U, Budde U, Lovis K, Dietrich T, Freitag A, Kupper L, Jahnisch K, Org. Process. Res. Dev., 13, 952 (2009)
Roydhouse MD, Ghaini A, Constantinou A, Cantu-Perez A, Motherwell WB, Gavriilidis A, Org. Process. Res. Dev., 15, 989 (2011)
Roydhouse MD, Motherwell WB, Constantinou A, Gavriilidis A, Wheeler R, Down K, Campbell I, RSC Adv., 3, 5076 (2013)
Irfan M, Glasnov TN, Kappe CO, Org. Lett., 13, 984 (2011)
Battilocchio C, Baxendale IR, Biava M, Kitching MO, Ley SV, Org. Process. Res. Dev., 16, 798 (2012)
Zak J, Ron D, Riva E, Harding HP, Cross BCS, Baxendale IR, Chem.-Eur. J., 18, 9901 (2012)
Fischer F, Tropsch H, Brennstoff-chem., 97 (1926)
Adkins H, Krsek G, J. Am. Chem. Soc., 71, 3051 (1949)
Sax NI, Lewis RJ, Dangerous properties of industrial materials, 7th Ed., Van Nostrand Reinhold (1989).
Miller PW, Long NJ, de Mello AJ, Vilar R, Passchier J, Gee A, Chem. Commun., 546 (2006)
Rahman MT, Fukuyama T, Kamata N, Sato M, Ryu I, Chem. Commun., 2236 (2006)
Murphy ER, Martinelli JR, Zaborenko N, Buchwald SL, Jensen KF, Angew. Chem.-Int. Edit., 46, 1734 (2007)
Miller PW, Long NJ, de Mello AJ, Vilar R, Audrain H, Bender D, Passchier J, Gee A, Angew. Chem.-Int. Edit., 46, 2875 (2007)
Miller PW, Jennings LE, de Mello AJ, Gee AD, Long NJ, Vilar R, Adv. Synth. Catal., 351, 3260 (2009)
Fukuyama T, Rahman MT, Kamata N, Ryu I, Beilstein J. Org. Chem., 5, 34 (2009)
Gong X, Miller PW, Gee AD, Long NJ, de Mello AJ, Vilar R, Chem.-Eur. J., 18, 2768 (2012)
Csajagi C, Borcsek B, Niesz K, Kovacs I, Szekelyhidi Z, Bajko Z, Urge L, Darvas F, Org. Lett., 10, 1589 (2008)
Koos P, Gross U, Polyzos A, O'Brien M, Baxendale I, Ley SV, Org. Biomol. Chem., 9, 6903 (2011)
Mercadante MA, Leadbeater NE, Org. Biomol. Chem., 9, 6575 (2011)
Kelly CB, Lee C, Mercadante MA, Leadbeater NE, Org. Process. Res. Dev., 15, 717 (2011)
Mercadante MA, Leadbeater NE, Green. Process. Synth., 1, 499 (2012)
Brancour C, Fukuyama T, Mukai Y, Skrydstrup T, Ryu I, Org. Lett., 15, 2794 (2013)
Fukuyama T, Mukai Y, Ryu I, Beilstein J. Org. Chem., 7, 1288 (2011)
Cartwright M, Wilkinson J, PROPELLANT-EXPLOS-PYROTECH, 35(4), 326 (2010)
Brase S, Gil C, Knepper K, Zimmermann V, Angew. Chem.-Int. Edit., 44, 5188 (2005)
Kopach ME, Murray MM, Braden TM, Kobierski ME, Williams OL, Org. Process. Res. Dev., 13, 152 (2009)
Weber M, Yilmaz G, Wille G, Chim. Oggi., 29, 8 (2011)
Delville MME, Nieuwland PJ, Janssen P, Koch K, van Hest JCM, Rutjes FPJT, Chem. Eng. J., 167(2-3), 556 (2011)
Smith CD, Baxendale IR, Lanners S, Hayward JJ, Smith SC, Ley SV, Org. Biomol. Chem., 5, 1559 (2007)
Baxendale IR, Ley SV, Mansfield AC, Smith CD, Angew. Chem.-Int. Edit., 48, 4017 (2009)
Kappe CO, Van der Eycken E, Chem. Soc. Rev., 39, 1280 (2010)
Ceylan S, Klande T, Vogt C, Friese C, Kirschning A, Synlett, 2010, 2009 (2010)
Varas AC, Noel T, Wang Q, Hessel V, ChemSusChem, 5, 1703 (2012)
Fuchs M, Goessler W, Pilger C, Kappe CO, Adv. Synth. Catal., 352, 323 (2010)
Bogdan AR, James K, Chem.-Eur. J., 16, 14506 (2010)
Bogdan AR, James K, Org. Lett., 13, 4060 (2011)
Bogdan AR, Sach NW, Adv. Synth. Catal., 351, 849 (2009)
Zhang P, Russell MG, Jamison TF, Org. Process. Res. Dev., 18, 1567 (2014)
Sahoo HR, Kralj JG, Jensen KF, Angew. Chem.-Int. Edit., 46, 5704 (2007)
Gutmann B, Roduit JP, Roberge D, Kappe CO, Angew. Chem.-Int. Edit., 49, 7101 (2010)
Gutmann B, Obermayer D, Roduit JP, Roberge DM, Kappe CO, J. Flow. Chem., 2, 8 (2012)
Flippin LA, Tetrahedron Lett., 32, 6857 (1991)
Talawar MB, Agrawal AP, Anniyappan M, Wani DS, Bansode MK, Gore GM, J. Hazard. Mater., 137(2), 1074 (2006)
Singh H, Chawla AS, Kapoor VK, Paul D, Malhotra RK, Prog. Med. Chem., 17, 151 (1980)
Herr RJ, Bioorg. Med. Chem., 10, 3379 (2002)
Gutmann B, Roduit JP, Roberge D, Kappe CO, Chem.-Eur. J., 17, 13146 (2011)
Brandt JC, Wirth T, Beilstein J. Org. Chem., 5, 30 (2009)
Viuf C, Bols M, Angew. Chem.-Int. Edit., 40, 623 (2001)
Pedersen CM, Marinescu LG, Bols M, Org. Biomol. Chem., 3, 816 (2005)
Linderman RJ, Jaber M, Griedel BD, J. Org. Chem., 59, 6499 (1994)
Berliner MA, Belecki K, J. Org. Chem., 70, 9618 (2005)
Barnes DM, Barkalow J, Plata DJ, Org. Lett., 11, 273 (2009)
Jasti A, Prakash S, Shahi VK, J. Membr. Sci., 428, 470 (2013)
Mitic A, Gernaey KV, Chem. Eng. Technol., 38(10), 1699 (2015)
Hosta-Rigau L, York-Duran MJ, Kang TS, Stadler B, Adv. Funct. Mater., 25(25), 3860 (2015)
Bogdan AR, Poe SL, Kubis DC, Broadwater SJ, McQuade DT, Angew. Chem.-Int. Edit., 121, 8699 (2009)
Mascia S, Heider PL, Zhang H, Lakerveld R, Benyahia B, Barton PI, Braatz RD, Cooney CL, Evans JMB, Jamison TF, Jensen KF, Myerson AS, Trout BL, Angew. Chem.-Int. Edit., 52, 12359 (2013)
Zhang P, Russell MG, Jamison TF, Org. Process. Res. Dev., 18, 1567 (2014)
Gilmore K, Kopetzki D, Lee JW, Horvath Z, McQuade DT, Seidel-Morgenstern A, Seeberger PH, Chem. Commun., 50, 12652 (2014)
Heider PL, Born SC, Basak S, Benyahia B, Lakerveld R, Zhang H, Hogan R, Buchbinder L, Wolfe A, Mascia S, Evans JMB, Jamison TF, Jensen KF, Org. Process. Res. Dev., 18, 402 (2014)
Petersen TP, Mirsharghi S, Rummel PC, Thiele S, Rosenkilde MM, Ritzen A, Ulven T, Chem.-Eur. J., 19, 9343 (2013)
Symes MD, Kitson PJ, Yan J, Richmond CJ, Cooper GJT, Bowman RW, Vilbrandt T, Cronin L, Nat. Chem., 4, 349 (2012)
Fitzpatrick DE, Battilocchio C, Ley SV, ACS Cent. Sci., 2(3), 131 (2016)
Au AK, Huynh W, Horowitz LF, Folch A, Angew. Chem.-Int. Edit., 55, 3862 (2016)
Whitesides GM, Nature, 442, 368 (2006)
Frost CG, Mutton L, Green Chem., 12, 1687 (2010)
Marre S, Jensen KF, Chem. Soc. Rev., 39, 1183 (2010)
Kockmann N, Roberge DM, Chem. Eng. Technol., 32(11), 1682 (2009)
Gutmann B, Cantillo D, Kappe CO, Angew. Chem.-Int. Edit., 54, 6688 (2015)
Mallia CJ, Baxendale IR, Org. Process. Res. Dev., 20, 327 (2016)
Porta R, Benaglia M, Puglisi A, Org. Process. Res. Dev., 20, 2 (2016)
Webb D, Jamison TF, Chem. Sci., 1, 675 (2010)
Wiles C, Watts P, Green Chem., 14, 38 (2012)
Deadman BJ, Collins SG, Maguire AR, Chem.-Eur. J., 21, 2298 (2015)
Muller STR, Wirth T, ChemSusChem, 8, 245 (2015)
Amii H, Nagaki A, Yoshida JI, Beilstein J. Org. Chem., 9, 2793 (2013)
Brzozowski M, O’Brien M, Ley SV, Polyzos A, Acc. Chem. Res., 48, 349 (2015)
Oger N, Le Grognec E, Felpin FX, Org. Chem. Front., 2, 590 (2015)
Newman SG, Jensen KF, Green Chem., 15, 1456 (2013)
McQuade DT, Seeberger PH, J. Org. Chem., 78, 6384 (2013)
Gemoets HPL, Su Y, Shang M, Hessel V, Luque R, Noel T, Chem. Soc. Rev., 45, 83 (2016)
Cossar PJ, Hizartzidis L, Simone MI, McCluskey A, Gordon CP, Org. Biomol. Chem., 13, 7119 (2015)
Singh AK, Ko DH, Vishwakarma NK, Jang S, Min KI, Kim DP, Nat. Commun., 7 (2016)
Maurya RA, Park CP, Lee JH, Kim DP, Angew. Chem.-Int. Edit., 50, 5952 (2011)
Mastronardi F, Gutmann B, Kappe CO, Org. Lett., 15, 5590 (2013)
O’Brien M, Baxendale IR, Ley SV, Org. Lett., 12, 1596 (2010)
Pinho VD, Gutmann B, Miranda LSM, de Souza ROMA, Kappe CO, J. Org. Chem., 79, 1555 (2014)
Pinho VD, Gutmann B, Kappe CO, RSC Adv., 4, 37419 (2014)
Rossi E, Woehl P, Maggini M, Org. Process. Res. Dev., 16, 1146 (2012)
Maas G, Angew. Chem.-Int. Edit., 48, 8186 (2009)
Maurya RA, Min KI, Kim DP, Green Chem., 16, 116 (2014)
Bartrum HE, Blakemore DC, Moody CJ, Hayes CJ, J. Org. Chem., 75, 8674 (2010)
Martin LJ, Marzinzik AL, Ley SV, Baxendale IR, Org. Lett., 13, 320 (2011)
Bailey PS, Chem. Rev., 58, 925 (1958)
Bailey PS, Ozonolysis in Organic Chemistry, Academic Press (1978).
Bunnelle WH, Chem. Rev., 91, 335 (1991)
Zvereva TI, Kasradze VG, Kazakova OB, Kukovinets OS, Russ. J. Org. Chem., 46, 1431 (2010)
Urben LBPG, Bretherick’s Handbook of Reactive Chemical Hazards, 7th Ed., Oxford (1990).
Caron P, Dugger RW, Ruggeri SG, Ragan JA, Ripin DHB, Chem. Rev., 106(7), 2943 (2006)
Wada Y, Schmidt MA, Jensen KF, Ind. Eng. Chem. Res., 45(24), 8036 (2006)
Hubner S, Bentrup U, Budde U, Lovis K, Dietrich T, Freitag A, Kupper L, Jahnisch K, Org. Process. Res. Dev., 13, 952 (2009)
Roydhouse MD, Ghaini A, Constantinou A, Cantu-Perez A, Motherwell WB, Gavriilidis A, Org. Process. Res. Dev., 15, 989 (2011)
Roydhouse MD, Motherwell WB, Constantinou A, Gavriilidis A, Wheeler R, Down K, Campbell I, RSC Adv., 3, 5076 (2013)
Irfan M, Glasnov TN, Kappe CO, Org. Lett., 13, 984 (2011)
Battilocchio C, Baxendale IR, Biava M, Kitching MO, Ley SV, Org. Process. Res. Dev., 16, 798 (2012)
Zak J, Ron D, Riva E, Harding HP, Cross BCS, Baxendale IR, Chem.-Eur. J., 18, 9901 (2012)
Fischer F, Tropsch H, Brennstoff-chem., 97 (1926)
Adkins H, Krsek G, J. Am. Chem. Soc., 71, 3051 (1949)
Sax NI, Lewis RJ, Dangerous properties of industrial materials, 7th Ed., Van Nostrand Reinhold (1989).
Miller PW, Long NJ, de Mello AJ, Vilar R, Passchier J, Gee A, Chem. Commun., 546 (2006)
Rahman MT, Fukuyama T, Kamata N, Sato M, Ryu I, Chem. Commun., 2236 (2006)
Murphy ER, Martinelli JR, Zaborenko N, Buchwald SL, Jensen KF, Angew. Chem.-Int. Edit., 46, 1734 (2007)
Miller PW, Long NJ, de Mello AJ, Vilar R, Audrain H, Bender D, Passchier J, Gee A, Angew. Chem.-Int. Edit., 46, 2875 (2007)
Miller PW, Jennings LE, de Mello AJ, Gee AD, Long NJ, Vilar R, Adv. Synth. Catal., 351, 3260 (2009)
Fukuyama T, Rahman MT, Kamata N, Ryu I, Beilstein J. Org. Chem., 5, 34 (2009)
Gong X, Miller PW, Gee AD, Long NJ, de Mello AJ, Vilar R, Chem.-Eur. J., 18, 2768 (2012)
Csajagi C, Borcsek B, Niesz K, Kovacs I, Szekelyhidi Z, Bajko Z, Urge L, Darvas F, Org. Lett., 10, 1589 (2008)
Koos P, Gross U, Polyzos A, O'Brien M, Baxendale I, Ley SV, Org. Biomol. Chem., 9, 6903 (2011)
Mercadante MA, Leadbeater NE, Org. Biomol. Chem., 9, 6575 (2011)
Kelly CB, Lee C, Mercadante MA, Leadbeater NE, Org. Process. Res. Dev., 15, 717 (2011)
Mercadante MA, Leadbeater NE, Green. Process. Synth., 1, 499 (2012)
Brancour C, Fukuyama T, Mukai Y, Skrydstrup T, Ryu I, Org. Lett., 15, 2794 (2013)
Fukuyama T, Mukai Y, Ryu I, Beilstein J. Org. Chem., 7, 1288 (2011)
Cartwright M, Wilkinson J, PROPELLANT-EXPLOS-PYROTECH, 35(4), 326 (2010)
Brase S, Gil C, Knepper K, Zimmermann V, Angew. Chem.-Int. Edit., 44, 5188 (2005)
Kopach ME, Murray MM, Braden TM, Kobierski ME, Williams OL, Org. Process. Res. Dev., 13, 152 (2009)
Weber M, Yilmaz G, Wille G, Chim. Oggi., 29, 8 (2011)
Delville MME, Nieuwland PJ, Janssen P, Koch K, van Hest JCM, Rutjes FPJT, Chem. Eng. J., 167(2-3), 556 (2011)
Smith CD, Baxendale IR, Lanners S, Hayward JJ, Smith SC, Ley SV, Org. Biomol. Chem., 5, 1559 (2007)
Baxendale IR, Ley SV, Mansfield AC, Smith CD, Angew. Chem.-Int. Edit., 48, 4017 (2009)
Kappe CO, Van der Eycken E, Chem. Soc. Rev., 39, 1280 (2010)
Ceylan S, Klande T, Vogt C, Friese C, Kirschning A, Synlett, 2010, 2009 (2010)
Varas AC, Noel T, Wang Q, Hessel V, ChemSusChem, 5, 1703 (2012)
Fuchs M, Goessler W, Pilger C, Kappe CO, Adv. Synth. Catal., 352, 323 (2010)
Bogdan AR, James K, Chem.-Eur. J., 16, 14506 (2010)
Bogdan AR, James K, Org. Lett., 13, 4060 (2011)
Bogdan AR, Sach NW, Adv. Synth. Catal., 351, 849 (2009)
Zhang P, Russell MG, Jamison TF, Org. Process. Res. Dev., 18, 1567 (2014)
Sahoo HR, Kralj JG, Jensen KF, Angew. Chem.-Int. Edit., 46, 5704 (2007)
Gutmann B, Roduit JP, Roberge D, Kappe CO, Angew. Chem.-Int. Edit., 49, 7101 (2010)
Gutmann B, Obermayer D, Roduit JP, Roberge DM, Kappe CO, J. Flow. Chem., 2, 8 (2012)
Flippin LA, Tetrahedron Lett., 32, 6857 (1991)
Talawar MB, Agrawal AP, Anniyappan M, Wani DS, Bansode MK, Gore GM, J. Hazard. Mater., 137(2), 1074 (2006)
Singh H, Chawla AS, Kapoor VK, Paul D, Malhotra RK, Prog. Med. Chem., 17, 151 (1980)
Herr RJ, Bioorg. Med. Chem., 10, 3379 (2002)
Gutmann B, Roduit JP, Roberge D, Kappe CO, Chem.-Eur. J., 17, 13146 (2011)
Brandt JC, Wirth T, Beilstein J. Org. Chem., 5, 30 (2009)
Viuf C, Bols M, Angew. Chem.-Int. Edit., 40, 623 (2001)
Pedersen CM, Marinescu LG, Bols M, Org. Biomol. Chem., 3, 816 (2005)
Linderman RJ, Jaber M, Griedel BD, J. Org. Chem., 59, 6499 (1994)
Berliner MA, Belecki K, J. Org. Chem., 70, 9618 (2005)
Barnes DM, Barkalow J, Plata DJ, Org. Lett., 11, 273 (2009)
Jasti A, Prakash S, Shahi VK, J. Membr. Sci., 428, 470 (2013)
Mitic A, Gernaey KV, Chem. Eng. Technol., 38(10), 1699 (2015)
Hosta-Rigau L, York-Duran MJ, Kang TS, Stadler B, Adv. Funct. Mater., 25(25), 3860 (2015)
Bogdan AR, Poe SL, Kubis DC, Broadwater SJ, McQuade DT, Angew. Chem.-Int. Edit., 121, 8699 (2009)
Mascia S, Heider PL, Zhang H, Lakerveld R, Benyahia B, Barton PI, Braatz RD, Cooney CL, Evans JMB, Jamison TF, Jensen KF, Myerson AS, Trout BL, Angew. Chem.-Int. Edit., 52, 12359 (2013)
Zhang P, Russell MG, Jamison TF, Org. Process. Res. Dev., 18, 1567 (2014)
Gilmore K, Kopetzki D, Lee JW, Horvath Z, McQuade DT, Seidel-Morgenstern A, Seeberger PH, Chem. Commun., 50, 12652 (2014)
Heider PL, Born SC, Basak S, Benyahia B, Lakerveld R, Zhang H, Hogan R, Buchbinder L, Wolfe A, Mascia S, Evans JMB, Jamison TF, Jensen KF, Org. Process. Res. Dev., 18, 402 (2014)
Petersen TP, Mirsharghi S, Rummel PC, Thiele S, Rosenkilde MM, Ritzen A, Ulven T, Chem.-Eur. J., 19, 9343 (2013)
Symes MD, Kitson PJ, Yan J, Richmond CJ, Cooper GJT, Bowman RW, Vilbrandt T, Cronin L, Nat. Chem., 4, 349 (2012)
Fitzpatrick DE, Battilocchio C, Ley SV, ACS Cent. Sci., 2(3), 131 (2016)
Au AK, Huynh W, Horowitz LF, Folch A, Angew. Chem.-Int. Edit., 55, 3862 (2016)
