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Received April 7, 2016
Accepted May 30, 2016
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Physical characteristics and in vitro skin permeation of elastic liposomes loaded with caffeic acid-hydroxypropyl-β-cyclodextrin
Department of Fine Chemistry, Cosmetic R&D Center, College of Energy and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Korea
snpark@seoultech.ac.kr
Korean Journal of Chemical Engineering, September 2016, 33(9), 2738-2746(9), 10.1007/s11814-016-0146-y
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Abstract
We developed a drug-in-cyclodextrin-in-elastic liposomes (DCEL) system to enhance transdermal delivery of caffeic acid (CA). Hydroxypropyl-β-cyclodextrin (HP-β-CD) was used as a hydrophilic CD. Elastic liposomes (EL) contained polyethylene glycol-free Tego® care 450 as an edge activator. Properties of the CA-HP-β-CD inclusion complex loaded in EL (CD-EL) as DCEL system were compared to characteristics of conventional liposomes (CL), EL, and CD-CL. Particle size, deformability, entrapment efficiency (EE%), stability, and vesicle morphology were characterized in liposome preparations. In addition, in vitro release and skin permeation were analyzed. We found that including Tego® care 450 reduced vesicle size and increased membrane deformability. The addition of HP-β-CD enhanced CA EE% of liposomes almost 1.6-fold that of liposomes without HP-β-CD. Moreover, CD-EL complex showed better controlled release profiles and higher skin permeability than CL and EL. We propose that the DCEL system can be a promising drug delivery vehicle for transdermal delivery of CA.
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References
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Cal K, Centkowska K, Eur. J. Pharm. Biopharm., 68, 467 (2008)
Kaur N, Puri R, Jain SK, Aaps PharmSciTech, 11, 528 (2010)
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Astorino TA, Alkadhi KA, in Caffeine: chemistry, analysis, function and effects, Preedy VR, Eds., Royal Society of Chemistry (2012).
Kim BY, Jeong JS, Kwon HJ, Lee JH, Hong SP, Kor. J. Herbol., 23, 67 (2008)
Fathi M, Mirlohi M, Varshosaz J, Madani G, J. Nanomater., 2013, 9 (2013)
Zhang M, Li J, Zhang L, Chao J, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 71, 1891 (2009)
Mohan PRK, Sreelakshmi G, Muraleedharan CV, Joseph R, Vib. Spectrosc., 62, 77 (2012)
van den Bergh BAI, Wertz PW, Junginger HE, Bouwstra JA, Int. J. Pharm., 217, 13 (2001)
Shaji J, Iyer S, Asian J. Pharm., 6, 218 (2012)
Delrivo A, Zoppi A, Longhi MR, Carbohydr. Polym., 87, 1980 (2012)
Liu B, Zhao J, Liu Y, Zhu X, Zeng J, J. Agric. Food Chem., 60, 12501 (2012)
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Hommoss A, PhD Thesis, Berlin, Free University of Berlin (2009).
Aggarwal N, Goindi S, Int. J. Pharm., 437, 277 (2012)
El Maghraby GMM, Williams AC, Barry BW, Int. J. Pharm., 276, 143 (2004)
Dhule SS, Penfornis P, Frazier T, Walker R, Feldman J, Tan G, He J, Alb A, John V, Pochampally R, Nanomedicine, 8, 440 (2012)
Agashe H, Lagisetty P, Sahoo K, Bourne D, Grady B, Awasthi V, J. Nanopart. Res., 13, 2609 (2011)
Shaji J, Lal M, Int. J. Curr. Pharm. Res., 6, 16 (2014)
Nava G, Pinon E, Mendoza L, Mendoza N, Quintanar D, Ganem A, Pharmaceutics, 3, 954 (2011)
Hussain A, Samad A, Ramzan M, Ahsan MN, Rehman ZU, Ahmad FJ, Drug. Deliv., 14, 1 (2014)
Singh HP, Tiwary AK, Jain S, Yakugaku Zasshi, 130, 397 (2010)
Lira MC, Ferraz MS, da Silva DG, Cortes ME, Teixeira KI, Caetano NP, Santos-Magalhaes NS, J. Incl. Phenom. Macrocycl. Chem., 64, 215 (2009)
Masson M, Loftsson T, Masson G, Stefansson E, J. Control. Release, 59, 107 (1999)
Nagarsenker MS, Amin L, Date AA, AAPS PharmSciTech, 9, 1165 (2008)
Chirio D, Cavalli R, Trotta F, Carlotti ME, Trotta M, J. Incl. Phenom. Macrocycl. Chem., 57, 645 (2007)
