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Received July 5, 2016
Accepted August 11, 2016
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Algicidal effects of thiazolinedione derivatives against Microcystis aeruginosa
Leaders in Industry-University Cooperation Foundation, Chosun University, Gwangju 61452, Korea 1Department of Polymer Science & Engineering, Chosun University, Gwangju 61452, Korea 2Biotechnology Laboratory, B-K Company Ltd., Jeonbuk 54008, Korea 3Biosystem Course, Division of Applied Sciences, Muroran Institute of Technology, 27-1 Mizumoto 050-8585, Japan
hcho@chosun.ac.kr
Korean Journal of Chemical Engineering, January 2017, 34(1), 139-149(11), 10.1007/s11814-016-0234-z
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Abstract
Novel algicidal compounds against Microcystis aeruginosa were developed. A series of 64 thiazolidinedione (TD) derivatives were synthesized and analyzed for algicidal activity. Eleven compounds (2, 22, 38, 40, 49, 52, 54, 56, 58, 60, and 63) showed potent specific algicidal activity against M. aeruginosa with IC50 values <0.5 μM. An acute ecotoxicity test for these compounds was conducted using Danio rerio for ten days to verify their environmental impacts. Compounds 2 and 22 presented low ecotoxicity (EC50 13.59 and 8.59 μM, respectively). To evaluate the ecotoxic effect of various concentrations of compound 2, Daphnia magna were treated with 2.0, 2.3, 2.7, or 3.0 μM compound 2 for 25 days. Survival rate was 100% after 25 days in the 2.0 μM group, but declined to 96% at 8 days and 30% at 17 days in the 2.3 μM group. Our results indicate that compound 2 could be a potential bio-agent for controlling harmful algal blooms.
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Baek SH, Hong SS, Song SY, Lee HO, Nakano SI, Han MS, J. Freshw Ecol., 24, 367 (2009)
Anderson DM, Ocean Coast Manage, 52, 342 (2009)
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Park TG, Lim WA, Park YT, Lee CK, Jeong HJ, Harm. Algae, 30S, S131 (2013)
Shumway SE, Frank DM, Ewart LM, Ward JE, Aquacult Res., 34, 1391 (2003)
Choi HG, Kim PJ, Lee WC, Yun SJ, Kim HG, Lee HJ, J. Korean Fish. Soc., 31, 109 (1998)
Lee YJ, Choi JK, Kim EK, Youn SH, Yang EJ, Harmful Algae, 7, 154 (2008)
Owens DR, Clin. Drug Invest., 22(8), 485 (2002)
Kim YM, Wu Y, Duong TU, Ghodake GS, Kim SW, Jin E, Cho H, Appl. Biochem. Biotechnol., 162(8), 2273 (2010)
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Han HK, Kim YM, Lim SS, Hong SG, Cho H, Int. J. Pharm., 405, 137 (2011)
Yim EC, Park IT, Han HK, Kim SI, Cho H, Kim SJ, Environ. Health Toxicol., 25, 273 (2010)
Kim SJ, Yim EC, Park IT, Kim SW, Cho H, Environ. Toxicol. Chem., 30, 2810 (2011)
Baek SH, Jang MC, Son MH, Joo HM, Cho HC, Kim YO, J. Korean Soc. Oceanog., 17, 9 (2012)
Ye WJ, Tan J, Liu XL, Lin SQ, Pan JL, Li DT, Yang H, Harm. Algae, 10, 472 (2011)
Zurawell RW, Chen H, Burke JM, Prepas EE, J. Toxicol. Environ. Health, 8, 1 (2005)
Ross C, Santiago-Vazquez L, Paul V, Aquat. Toxicol., 78, 66 (2006)
Li ZH, Geng MX, Yang H, Appl. Microbiol. Biotechnol., 99(2), 981 (2015)
Kim YM, Wu Y, Duong TU, Jung SG, Kim SW, Cho H, Jin ES, Mar. Biotechnol., 14, 312 (2012)
