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Received April 26, 2017
Accepted July 21, 2017
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Statistical optimization of curcumin nanosuspension through liquid anti-solvent precipitation (LASP) process in a microfluidic platform: Box-Behnken design approach
CFD Research Center, Chemical Engineering Department, Razi University, Kermanshah, Iran 1Chemical Engineering Department, Kermanshah University of Technology, Kermanshah, Iran
h_rashidi@kut.ac.ir
Korean Journal of Chemical Engineering, November 2017, 34(11), 3017-3027(11), 10.1007/s11814-017-0201-3
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Abstract
The paper deals with the development and optimization of curcumin nanosuspension by solvent/anti-solvent precipitation method in a microfluidic platform. A three-level Box-Behnken design was applied as an optimizing technique to investigate the effect of three independent operating variables, namely, volume ratios of anti-solvent to solvent, flow rate of drug solution, and curcumin concentration on the preferred response. In presence of PVP as the stabilizer, a nano-curcumin suspension was obtained in the range of 62-335nm. Analysis of variance showed that the variables with the highest effect were the linear effects of the anti-solvent to solvent ratio, and its corresponding squared term. Applying response surface methodology, curcumin nanosuspension with average size of 63.12 nm can be obtained under optimum condition As: S=15, solvent flow rate of 1.0mL/min and curcumin ethanolic concentration of 5.0mg/mL. The prepared nanoparticles were further characterized by infrared spectroscopy, scanning electron microscopy, and X-ray diffraction tests.
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Box GE, Wilson K, J. R. Stat. Soc. Series B, 13, 1 (1951)
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Sengupta A, Kamble PD, Basu JK, Sengupta S, Ind. Eng. Chem. Res., 51, 147 (2011)
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Kim S, Ng WK, Dong Y, Das S, Tan RBH, J. Food Eng., 108(1), 37 (2012)
