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Received September 30, 2016
Accepted November 26, 2016
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Hypolipidemic and antioxidant effects on hypercholesterolemic rats of polysaccharide from Salicornia bigelovii seed
Dong-Hoon Lim
Dubok Choi1
Sun-Mi Kim2
YuLan Piao2
On-You Choi3
Geum-Sook Lim4
Young-Cheol Chang5
Hoon Cho2†
Department of Urology, School of Medicine, Chosun University, Gwangju 61452, Korea 1Biotechnology Laboratory, B-K Company Ltd., Jeonbuk 54008, Korea 2Department of Biochemical Polymer Science & Engineering, Chosun University, Gwangju 61452, Korea 3Biochem Lab., Shinchon E&C R&D, Gwangju 61165, Korea 4Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University Graduate School, Gwangju 61186, Korea 5Biosystem Course, Division of Applied Sciences, Muroran Institute of Technology, 27-1 Mizumoto, Muroran 050-8585, Japan
hcho@chosun.ac.kr
Korean Journal of Chemical Engineering, March 2017, 34(3), 787-796(10), 10.1007/s11814-016-0335-8
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Abstract
The hypolipidemic and antioxidant effects of dietary supplementation with polysaccharide isolated from Salicornia bigelovii seed (SBS) were evaluated in hypercholesterolemic rats. Following administration of SBS polysaccharide at 200mg/kg BW/day (HPS group), total cholesterol (TC), and low density lipoprotein cholesterol (LDLC) levels were 32.45% and 58.09% lower than those in negative controls (NC) group, respectively. However, in the case of high density lipoprotein cholesterol (HDLC), it was 36.37% higher than that of NC group. The arteriosclerosis and cardiac risk indices were 64.23% and 50.53% lower than in the NC group. However, the HTR (HDLC/TC) value was higher 2.05-fold than that of the NC group. Hydroxy-3-methylglutaryl CoA reductase activity in HPS group was 55.1% lower than that of the NC group. Activities of alanine transferase, aspartate aminotransferase, and alkaline phosphatase in HPS group were 29.71%, 26.49%, and 32.24%, lower than that of the NC group. SOD, CAT, and GSH-Px activities in HPS group were 31.05%, 49.29%, and 54.62% higher than that of the NC group. These results indicate that SBS polysaccharide has both hypolipidemic and antioxidant effects and shows potential for ameliorating hypercholesterolemia.
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Kang SM, Kim DR, Lee BH, Kim MR, Choang MH, Ho JG, Food Sci. Biotechnol., 20, 115 (2011)
Sung JH, Park SH, Seo DH, Lee JH, Hong SW, Hong SS, Biosci., Biotechnol., Biochem., 73, 552 (2009)
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Kang HK, Koppula SH, Park TK, Tropical J. Pharmaceutical Res., 12, 897 (2013)
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Gillies PJ, Rathge KA, Robinson CS, Experi. Mol. Pathology, 44, 329 (1986)
Im SA, Kim KJ, Lee CK, Inter. Immunopharmacol., 6, 1451 (2006)
Ryu DS, Kim SH, Seok DS, Food Sci. Biotechnol., 18, 1481 (2009)
Lee KY, Lee MH. Chang IY, Yoon SP, Lim DY, Jeon YJ, J. Ethnopharmacol., 103, 372 (2006)
Lee MY, Kim KH, Kim YH, Lee DS, Kor. J. Microbiol. Biotechnol., 36, 43 (2008)
Ryu DS, Kim SH, Lee DS, J. Microbiol. Biotechnol., 19, 1482 (2009)
Wang Y, Yang Z, Wie X, Int. J. Biol. Macromol., 47, 534 (2010)
Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EG, Swapna S, Ramesh B, Rao CA, Food Chem. Toxicol., 48, 1078 (2010)
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Qureshi AA, Diz ZZ, Abuirmeileh N, Bugger CC, Ahmad Y, Elson CEJ, Nutri., 113, 1746 (1983)
Konjufca VH, Pesti GM, Balkali RI, Poultry Sci., 76, 1264 (1997)
Evans J, Hood RL, Oakenfull DG, Sidhu GS, Br. J. Nutr., 68, 217 (1992)
Cheung PCK, Nutr. Res., 16, 1953 (1996)
Bocan TMA, Mueller BS, Uhendrof PD, Newton RS, Kraus BR, Arteriosclerosis Thrombosis, 11, 1830 (1991)
Lee HJ, Choi MS, J. Food Sci. Nutr., 4, 344 (1998)
Kupeli E, Orhan DD, Yesilada E, J. Ethnopharmacol., 103, 455 (2006)
Yamaguchi M, Yamaguchi R, Biochem. Pharmacol., 35, 773 (1986)
Jain KS, Kathiravan MK, Somani RS, Shishoo CJ, Bioorg. Med. Chem. Lett., 15, 4674 (2007)
Tomas M, Latorre G, Senti M, Marrugat J, Revista Espanola de Cardiologia, 57, 557 (2004)
Ohara Y, Peterson TE, Harrison DG, J. Clinical Investigation, 91, 2546 (1993)
Devi gs, Prasad MH, Saraswathi I, Raghu D, Rao DN, Reddy PP, Clin. Chim. Acta, 293, 53 (2000)
Harman D, Proc. Natl. Acad. Sci., 88, 5360 (1991)
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Kwon MJ, Joun YS, Song YO, J. Korean Soc. Food Nutr., 23, 899 (1994)
