Articles & Issues
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
-
Received August 19, 2016
Accepted February 2, 2017
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
All issues
Effects of solvents on rheological and crosslinking properties of photo-polymerized poly(ethylene glycol) hydrogels
Kevin Injoe Jung
Dong Geun Lee
Ki Wan Bong
Seung Man Noh1
Min Seop Um2
Woo Jin Choi2
Bumsang Kim3†
Hyun Wook Jung†
Department of Chemical and Biological Engineering, Korea University, Seoul 02841, Korea 1Research Center for Green Fine Chemicals, Korea Research Institute of Chemical Technology, Ulsan 44412 Korea 2Chemical Materials Solutions Center, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea 3Department of Chemical Engineering, Hongik University, Seoul 04066, Korea
bskim@hongik.ac.kr
Korean Journal of Chemical Engineering, May 2017, 34(5), 1517-1523(7), 10.1007/s11814-017-0013-5
Download PDF
Abstract
The effects of solvents such as water and ethanol on the rheological properties and crosslinking characteristics of poly(ethylene glycol) (PEG) hydrogels were examined. Real-time storage modulus data for pre-polymerized mixtures containing different solvents during the photo-polymerization process successfully explained the differences in the formation of crosslinked networks of the corresponding hydrogels. Various experimental methods for Fourier transform infrared spectroscopy (FT-IR), swelling ratio, Rhodamine-B (Rh-B) loading/release properties, and scratch/indentation depths on hydrogel surfaces, were employed to systematically compare macroscopic structural and mechanical properties of the crosslinked PEG hydrogels with different solvents (water and ethanol). The effects of the solvents on the hydrogel properties were satisfactorily consistent, and the results clearly indicated that water hindered the formation of the crosslinked network more severely than ethanol at the same weight ratio because of the presence of larger number of water molecules in pre-polymerized mixtures, which was a more favorable feature for water than ethanol in the initial crosslinking growth.
Keywords
References
Langer R, Peppas NA, AIChE J., 49(12), 2990 (2003)
Peppas N, Bures P, Leobandung W, Ichikawa H, Eur. J. Pharm. Biopharm., 50, 27 (2000)
Lee E, Kim B, Korean J. Chem. Eng., 28(6), 1347 (2011)
Chaturvedi K, Ganguly K, Nadagouda MN, Aminabhavi TM, J. Control. Release, 165, 129 (2013)
Lee SC, Kwon IK, Park K, Adv. Drug Deliv. Rev., 65, 17 (2013)
Na YH, Oh HY, Ahn YJ, Han Y, Korea-Aust. Rheol. J., 27(1), 25 (2015)
Killion JA, Geever LM, Devine DW, Kennedy JE, Higginbotham CL, J. Mech. Behav. Biomed, 4, 1219 (2011)
Ju H, McCloskey BD, Sagle AC, Wu YH, Kusuma VA, Freeman BD, J. Membr. Sci., 307(2), 260 (2008)
Bader RA, Rochefort WE, J. Biomed. Mater. Res. A., 86, 494 (2008)
Buwalda SJ, Calucci L, Forte C, Dijkstra PJ, Feijen J, Polymer, 53(14), 2809 (2012)
Censi R, Fieten PJ, di Martino P, Hennink WE, Vermonden T, Macromolecules, 43(13), 5771 (2010)
Wang J, Ugaz VM, Electrophoresis, 27(17), 3349 (2006)
Bonino CA, Samorezov JE, Jeon O, Alsberg E, Khan SA, Soft Matter, 7, 11510 (2011)
Khan S, Plitz I, Frantz R, Rheol. Acta, 31, 151 (1992)
Chiou BS, Kham SA, Macromolecules, 30(23), 7322 (1997)
Hwang JW, Noh SM, Kim B, Jung HW, J. Appl. Polym. Sci., 132, 22 (2015)
Kang GD, Cao YM, Zhao HY, Yuan Q, J. Membr. Sci., 318(1-2), 227 (2008)
Ju H, McCloskey BD, Sagle AC, Kusuma VA, Freeman BD, J. Membr. Sci., 330(1-2), 180 (2009)
Lin HQ, Kai T, Freeman BD, Kalakkunnath S, Kalika DS, Macromolecules, 38(20), 8381 (2005)
Lin H, Van Wagner E, Swinnea JS, Freeman BD, Pas SJ, Hill AJ, Kalakkunnath S, Kalika DS, J. Membr. Sci., 276, 145 (2006)
Ju H, McCloskey BD, Sagle AC, Wu YH, Kusuma VA, Freeman BD, J. Membr. Sci., 307(2), 260 (2008)
Bryant SJ, Anseth KS, J. Biomed. Mater. Res., 59, 63 (2002)
Hood RR, Shao C, Omiatek DM, Vreeland WN, DeVoe DL, Pharm. Res., 30, 1597 (2013)
Suggs LJ, Shive MS, Garcia CA, Anderson JM, Mikos AG, J. Biomed. Mater. Res., 46, 22 (1999)
Dal Pozzo A, Vanini L, Fagnoni M, Guerrini M, De Benedittis A, Muzzarelli R, Carbohydr. Polym., 42, 201 (2000)
Roach P, McGarvey DJ, Lees MR, Hoskins C, Int. J. Mol. Sci., 14(4), 8585 (2013)
Lin GY, Tarasevich B, J. Appl. Polym. Sci., 128(6), 3534 (2013)
Tan GX, Liao JW, Ning CY, Zhang L, J. Appl. Polym. Sci., 125(5), 3509 (2012)
Ikeda Y, Katamachi J, Kawasaki H, Nagasaki Y, Bioconjugate Chem., 24, 1824 (2013)
Ravi N, Mitra A, Hamilton P, Horkay F, J. Polym. Sci. B: Polym. Phys., 40(23), 2677 (2002)
Valdebenito A, Encinas MV, Polym. Int., 59, 1246 (2010)
Beuermann S, Macromol. Rapid Commun., 30(13), 1066 (2009)
Mellott MB, Searcy K, Pishko MV, Biomaterials, 22, 929 (2001)
Kloxin AM, Kasko AM, Salinas CN, Anseth KS, Science, 324, 59 (2009)
Andreopoulos FM, Beckman EJ, Russell AJ, Biomaterials, 19, 1343 (1998)
Mansur HS, Orefice RL, Mansur AAP, Polymer, 45(21), 7193 (2004)
Zhang R, Hummelgard M, Lv G, Olin H, Carbon, 49, 1126 (2011)
Consiglio R, Randall NX, Bellaton B, von Stebut J, Thin Solid Films, 332(1-2), 151 (1998)
Noh SM, Lee JW, Nam JH, Byun KH, Park JM, Jung HW, Prog. Org. Coat., 74, 257 (2012)
Hwang JW, Kim KN, Noh SM, Jung HW, J. Coat. Technol. Res., 12, 177 (2015)
Mizuno K, Miyashita Y, Shindo Y, Ogawa H, J. Phys. Chem., 99(10), 3225 (1995)
Peppas N, Bures P, Leobandung W, Ichikawa H, Eur. J. Pharm. Biopharm., 50, 27 (2000)
Lee E, Kim B, Korean J. Chem. Eng., 28(6), 1347 (2011)
Chaturvedi K, Ganguly K, Nadagouda MN, Aminabhavi TM, J. Control. Release, 165, 129 (2013)
Lee SC, Kwon IK, Park K, Adv. Drug Deliv. Rev., 65, 17 (2013)
Na YH, Oh HY, Ahn YJ, Han Y, Korea-Aust. Rheol. J., 27(1), 25 (2015)
Killion JA, Geever LM, Devine DW, Kennedy JE, Higginbotham CL, J. Mech. Behav. Biomed, 4, 1219 (2011)
Ju H, McCloskey BD, Sagle AC, Wu YH, Kusuma VA, Freeman BD, J. Membr. Sci., 307(2), 260 (2008)
Bader RA, Rochefort WE, J. Biomed. Mater. Res. A., 86, 494 (2008)
Buwalda SJ, Calucci L, Forte C, Dijkstra PJ, Feijen J, Polymer, 53(14), 2809 (2012)
Censi R, Fieten PJ, di Martino P, Hennink WE, Vermonden T, Macromolecules, 43(13), 5771 (2010)
Wang J, Ugaz VM, Electrophoresis, 27(17), 3349 (2006)
Bonino CA, Samorezov JE, Jeon O, Alsberg E, Khan SA, Soft Matter, 7, 11510 (2011)
Khan S, Plitz I, Frantz R, Rheol. Acta, 31, 151 (1992)
Chiou BS, Kham SA, Macromolecules, 30(23), 7322 (1997)
Hwang JW, Noh SM, Kim B, Jung HW, J. Appl. Polym. Sci., 132, 22 (2015)
Kang GD, Cao YM, Zhao HY, Yuan Q, J. Membr. Sci., 318(1-2), 227 (2008)
Ju H, McCloskey BD, Sagle AC, Kusuma VA, Freeman BD, J. Membr. Sci., 330(1-2), 180 (2009)
Lin HQ, Kai T, Freeman BD, Kalakkunnath S, Kalika DS, Macromolecules, 38(20), 8381 (2005)
Lin H, Van Wagner E, Swinnea JS, Freeman BD, Pas SJ, Hill AJ, Kalakkunnath S, Kalika DS, J. Membr. Sci., 276, 145 (2006)
Ju H, McCloskey BD, Sagle AC, Wu YH, Kusuma VA, Freeman BD, J. Membr. Sci., 307(2), 260 (2008)
Bryant SJ, Anseth KS, J. Biomed. Mater. Res., 59, 63 (2002)
Hood RR, Shao C, Omiatek DM, Vreeland WN, DeVoe DL, Pharm. Res., 30, 1597 (2013)
Suggs LJ, Shive MS, Garcia CA, Anderson JM, Mikos AG, J. Biomed. Mater. Res., 46, 22 (1999)
Dal Pozzo A, Vanini L, Fagnoni M, Guerrini M, De Benedittis A, Muzzarelli R, Carbohydr. Polym., 42, 201 (2000)
Roach P, McGarvey DJ, Lees MR, Hoskins C, Int. J. Mol. Sci., 14(4), 8585 (2013)
Lin GY, Tarasevich B, J. Appl. Polym. Sci., 128(6), 3534 (2013)
Tan GX, Liao JW, Ning CY, Zhang L, J. Appl. Polym. Sci., 125(5), 3509 (2012)
Ikeda Y, Katamachi J, Kawasaki H, Nagasaki Y, Bioconjugate Chem., 24, 1824 (2013)
Ravi N, Mitra A, Hamilton P, Horkay F, J. Polym. Sci. B: Polym. Phys., 40(23), 2677 (2002)
Valdebenito A, Encinas MV, Polym. Int., 59, 1246 (2010)
Beuermann S, Macromol. Rapid Commun., 30(13), 1066 (2009)
Mellott MB, Searcy K, Pishko MV, Biomaterials, 22, 929 (2001)
Kloxin AM, Kasko AM, Salinas CN, Anseth KS, Science, 324, 59 (2009)
Andreopoulos FM, Beckman EJ, Russell AJ, Biomaterials, 19, 1343 (1998)
Mansur HS, Orefice RL, Mansur AAP, Polymer, 45(21), 7193 (2004)
Zhang R, Hummelgard M, Lv G, Olin H, Carbon, 49, 1126 (2011)
Consiglio R, Randall NX, Bellaton B, von Stebut J, Thin Solid Films, 332(1-2), 151 (1998)
Noh SM, Lee JW, Nam JH, Byun KH, Park JM, Jung HW, Prog. Org. Coat., 74, 257 (2012)
Hwang JW, Kim KN, Noh SM, Jung HW, J. Coat. Technol. Res., 12, 177 (2015)
Mizuno K, Miyashita Y, Shindo Y, Ogawa H, J. Phys. Chem., 99(10), 3225 (1995)
