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Received August 17, 2016
Accepted March 13, 2017
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Controlled drug release in silicone adhesive utilizing particulate additives
Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Gangwondo 26493, Korea 1University of College,, Yonsei University, Incheon 21983, Korea
Korean Journal of Chemical Engineering, June 2017, 34(6), 1600-1603(4), 10.1007/s11814-017-0069-2
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Abstract
Polydimethylsiloxane (PDMS) based adhesives were prepared by cross-linking tetraethoxyorthosilicate (TEOS) while controlling stoichiometry with PDMS, acid catalyst, and water. Particulate additives, alginate and bentonite, were added during the cross-linking process. Cationic drug lidocaine was incorporated into the adhesive with or without additive, and the time-dependent drug release profile was evaluated in phosphate buffered saline and ethanol, respectively. According to kinetic fitting to power function and parabolic diffusion, both solvent and additive type influenced drug release. In particular, particulate additives were found to suppress or facilitate drug release in water or ethanol, respectively.
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Belanger MC, Marois Y, J. Biomed. Mater. Res., 58, 467 (2001)
Defrere S, Mestagdt M, Riva R, Krier F, Van Langendonckt A, Drion P, Jerome C, Evrard B, Dehoux JP, Foidart JM, Macromol. Biosci., 11, 1366 (2011)
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Havlin J, Westfall D, Olsen S, Soil Sci. Soc. Am. J., 49, 371 (1985)
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Arora P, Mukherjee B, J. Pharm. Sci., 91, 2076 (2002)
Yang H, Nguyen QT, Ding YD, Long YC, Ping ZH, J. Membr. Sci., 164(1-2), 37 (2000)
