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Received December 2, 2015
Accepted May 14, 2017
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Preparation of cationic functional polymer poly(Acryloxyethyltrimethyl ammonium chloride)/SiO2 and its adsorption characteristics for heparin
Department of Chemical Engineering, North University of China, Taiyuan 030051, P. R. China
Korean Journal of Chemical Engineering, July 2017, 34(7), 1889-1895(7), 10.1007/s11814-017-0131-0
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Abstract
Ion-exchange is a widely used purification technology in the heparin manufacturing process. To improve the rate and efficiency, the cationic monomer Acryloxyethyltrimethyl ammonium chloride (DAC) was grafted on silica gel particles by using a surface-initiated graft-polymerization technique, and a novel adsorption polymer of PDAC/SiO2 was prepared. The adsorption experiments of PDAC/SiO2 for heparin show that there are strong electrostatic interactions between heparin with a high density of negative charges and PDAC/SiO2 that exists in many quaternary ammonium cations. Comparing the adsorption kinetics of PDAC/SiO2 with D201 anionic strong alkali exchange resin, PDAC/SiO2 shows higher adsorption capacity and faster adsorption rate. The pH and temperature of solutions have a great influence on the adsorption amount, and there is a maximum adsorption capacity of 121mg/g when pH=7 at 25 °C. The adsorption of PDAC/SiO2 for heparin is an exothermic process and driven by entropy.
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