Articles & Issues
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
-
Received November 24, 2016
Accepted March 16, 2017
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
All issues
Morphological, thermal and drug release studies of poly (methacrylic acid)-based molecularly imprinted polymer nanoparticles immobilized in electrospun poly (ε-caprolactone) nanofibers as dexamethasone delivery system
Payam Zahedi†
Mahshid Fallah-Darrehchi
Shima Ahmadi Nadoushan
Robabeh Aeinehvand
Lida Bagheri
Mohammad Najafi
Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, P. O. Box, 11155-4563, Tehran, Iran
phdzahedi@ut.ac.ir
Korean Journal of Chemical Engineering, July 2017, 34(7), 2110-2118(9), 10.1007/s11814-017-0078-1
Download PDF
Abstract
Electrospun poly (ε-caprolactone) (PCL) nanofibers containing molecularly imprinted polymer (MIP) nanoparticles based on methacrylic acid (MAA) were prepared for controlled release of dexamethasone (Dexa). First, the MIPs consisting of Dexa were synthesized via precipitation polymerization. Their recognition sites formation and thermal properties were investigated by FTIR and TGA tests, respectively. The results showed that by selecting a monomer: template (MAA:Dexa) molar ratio of 6 : 1, MIP nanoparticles were produced with imprinting factor of 1.80. The FESEM and TEM images showed the MIPs average diameter of 394±9.7 nm and appropriate immobilization of them in PCL nanofibers, respectively. Moreover, the cumulative release of Dexa from the MIP-loaded nanofibrous samples was studied by UV-vis spectrophotometry and revealed a suitable controlled release of the drug during four days. Afterward, Dexa release followed Higuchi model which indicated the main mechanism was governed by Fickian diffusion theory.
Keywords
References
Kim DH, Martin DC, Biomaterials, 27, 3031 (2006)
Chronakis IS, Jakob A, Hagstrom B, Ye L, Langmuir, 22(21), 8960 (2006)
Pan Q, Xu Q, Boylan NJ, Lamb NW, Emmert DG, Yang JC, Tang L, Heflin T, Alwadani S, Eberhart CG, J. Control. Release, 201, 32 (2015)
Kalam MA, Int. J. Biol. Macromol., 89, 559 (2016)
Vacanti NM, Cheng H, Hill PS, Guerreiro JDT, Dang TT, Ma ML, Watson S, Hwang NS, Langer R, Anderson DG, Biomacromolecules, 13(10), 3031 (2012)
Li JR, Fu R, Li L, Yang G, Ding S, Zhong ZD, Zhou SB, Pharm. Res.-Dordr., 31, 1632 (2014)
Chen WM, Li DW, EI-Shanshory A, El-Newehy M, EIHamshary HA, Al-Deyab SS, He CL, Mo XM, Colloids Surf. B: Biointerfaces, 126, 561 (2015)
Li YF, Rubert M, Yu Y, Besenbacher F, Chen ML, Rsc Adv., 5, 34166 (2015).
Giovannoli C, Passini C, Anfossi L, Nardo FD, Spano G, Maurino V, Baggiani C, J. Sep. Sci., 38, 3661 (2015)
Takimoto K, Takano E, Kitayama Y, Takeuchi T, Langmuir, 31(17), 4981 (2015)
Pourfarzib M, Shekarchi M, Rastegar H, Akbari-Adergani B, Mehramizi A, Dinarvand R, J. Chromatogr. B, 974, 1 (2015)
Asadi E, Azodi-Deilami S, Abdouss M, Kordestani D, Rahimi A, Asadi S, Korean J. Chem. Eng., 31(6), 1028 (2014)
Shi YF, Lv HL, Lu XF, Huang YX, Zhang Y, Xue W, J. Mater. Chem., 22, 3889 (2012)
Gan Q, Zhu J, Yuan Y, Liu H, Qian J, Li Y, Liu C, J. Mater. Chem., 3, 2056 (2015)
Sellergren B, Hall AJ, Molecularly imprinted polymers: From molecules to nanomaterials, John Wiley & Sons Ltd., New York (2012).
Ye L, Mosbach K, Chem. Mat., 20, 859 (2008)
Javanbakht M, Attaran AM, Namjumanesh MH, Esfandyari-Manesh M, Akbari-Adergani B, J. Chromatogr. B, 878, 1700 (2010)
Wulff G, Chem. Rev., 102(1), 1 (2002)
Mirata F, Resmini M, Molecularly imprinted polymers in biotechnology, Springer, Heidelberg (2015).
Haupt K, Mosbach K, Chem. Rev., 100(7), 2495 (2000)
Mazzotta E, Turco A, Chianella I, Guerreiro A, Piletsky SA, Malitesta C, Sensor. Actuat. B-Chem., 229, 174 (2016)
Turiel E, Alvarez MD, Esteban AM, J. Chromatogr. A, 1432, 1 (2016)
Su X, Li X, Li J, Liu M, Lei F, Tan X, Li P, Luo W, Food Chem., 171, 292 (2015)
Kempe M, Mosbach K, Fischer L, J. Mol. Recognit., 6, 25 (1993)
Yin J, Yang G, Chen Y, J. Chromatogr. A, 1090, 68 (2005)
Yang Y, Liu X, Guo M, Li S, Liu W, Xu B, Colloids Surf. A: Physicochem. Eng. Asp., 377, 379 (2011)
Caro E, Marce RM, Cormack PAG, Sherrington DC, Borrull F, J. Chromatogr. A, 1047, 175 (2004)
Zahedi P, Rezaeian I, Jafari SH, Karami Z, Macromol. Res., 21(6), 649 (2013)
Nguyen LTH, Liao S, Chan CK, Ramakrishna S, . Biomat. Sci.-Polym. E., 23, 1771 (2012)
Manesh ME, Javanbakht M, Atyabi F, Mohammadi A, Mohammadi S, Adergani BA, Dinarvand R, Mat. Sci. Eng. C-Mater., 31, 1692 (2011)
Abdouss M, Asadi E, Deilami SA, mohammadi NB, Aslanzadeh SA, J. Mater. Sci. -Mater. Med., 22, 2273 (2011)
Hiratani H, Fujiwara A, Tamiya Y, Mizutani Y, Lorenzo CA, Biomaterials, 26, 1293 (2005)
Malaekeh-Nikouei B, Ghaeni FA, Motamedshariaty VS, Mohajeri SA, J. Appl. Polym. Sci., 126(1), 387 (2012)
Lu XF, Shi YF, Lv HL, Fu YY, Ma D, Xue W, J. Mater. Sci. -Mater. Med., 25, 1461 (2014)
Cirillo G, Curcio M, Parisi OI, Puoci F, Iemma F, Spizzirri UG, Restuccia D, Picci N, Food Chem., 125, 1058 (2011)
Mohebali A, Abdouss M, Mazinani S, Zahedi P, Polym. Adv. Technol., 27, 1164 (2016)
Zhang L, Guo Y, Chi WH, Shi HG, Ren HQ, Guo TY, Chin. J. Polym. Sci., 32, 1469 (2014)
Hickey T, Kreutzer D, Burgess DJ, Moussy F, J. Biomed. Mater. Res., 61, 180 (2002)
Miura C, Matsunaga H, Haginaka J, J. Pharmaceut. Biomed., 127, 32 (2016)
Nakamura Y, Matsunaga H, Haginaka J, J. Sep. Sci., 39, 1542 (2016)
Zamani M, Morshed M, Varshosaz J, Jannesari M, Eur. J. Pharm. Biopharm., 75, 179 (2010)
Chronakis IS, Jakob A, Hagstrom B, Ye L, Langmuir, 22(21), 8960 (2006)
Pan Q, Xu Q, Boylan NJ, Lamb NW, Emmert DG, Yang JC, Tang L, Heflin T, Alwadani S, Eberhart CG, J. Control. Release, 201, 32 (2015)
Kalam MA, Int. J. Biol. Macromol., 89, 559 (2016)
Vacanti NM, Cheng H, Hill PS, Guerreiro JDT, Dang TT, Ma ML, Watson S, Hwang NS, Langer R, Anderson DG, Biomacromolecules, 13(10), 3031 (2012)
Li JR, Fu R, Li L, Yang G, Ding S, Zhong ZD, Zhou SB, Pharm. Res.-Dordr., 31, 1632 (2014)
Chen WM, Li DW, EI-Shanshory A, El-Newehy M, EIHamshary HA, Al-Deyab SS, He CL, Mo XM, Colloids Surf. B: Biointerfaces, 126, 561 (2015)
Li YF, Rubert M, Yu Y, Besenbacher F, Chen ML, Rsc Adv., 5, 34166 (2015).
Giovannoli C, Passini C, Anfossi L, Nardo FD, Spano G, Maurino V, Baggiani C, J. Sep. Sci., 38, 3661 (2015)
Takimoto K, Takano E, Kitayama Y, Takeuchi T, Langmuir, 31(17), 4981 (2015)
Pourfarzib M, Shekarchi M, Rastegar H, Akbari-Adergani B, Mehramizi A, Dinarvand R, J. Chromatogr. B, 974, 1 (2015)
Asadi E, Azodi-Deilami S, Abdouss M, Kordestani D, Rahimi A, Asadi S, Korean J. Chem. Eng., 31(6), 1028 (2014)
Shi YF, Lv HL, Lu XF, Huang YX, Zhang Y, Xue W, J. Mater. Chem., 22, 3889 (2012)
Gan Q, Zhu J, Yuan Y, Liu H, Qian J, Li Y, Liu C, J. Mater. Chem., 3, 2056 (2015)
Sellergren B, Hall AJ, Molecularly imprinted polymers: From molecules to nanomaterials, John Wiley & Sons Ltd., New York (2012).
Ye L, Mosbach K, Chem. Mat., 20, 859 (2008)
Javanbakht M, Attaran AM, Namjumanesh MH, Esfandyari-Manesh M, Akbari-Adergani B, J. Chromatogr. B, 878, 1700 (2010)
Wulff G, Chem. Rev., 102(1), 1 (2002)
Mirata F, Resmini M, Molecularly imprinted polymers in biotechnology, Springer, Heidelberg (2015).
Haupt K, Mosbach K, Chem. Rev., 100(7), 2495 (2000)
Mazzotta E, Turco A, Chianella I, Guerreiro A, Piletsky SA, Malitesta C, Sensor. Actuat. B-Chem., 229, 174 (2016)
Turiel E, Alvarez MD, Esteban AM, J. Chromatogr. A, 1432, 1 (2016)
Su X, Li X, Li J, Liu M, Lei F, Tan X, Li P, Luo W, Food Chem., 171, 292 (2015)
Kempe M, Mosbach K, Fischer L, J. Mol. Recognit., 6, 25 (1993)
Yin J, Yang G, Chen Y, J. Chromatogr. A, 1090, 68 (2005)
Yang Y, Liu X, Guo M, Li S, Liu W, Xu B, Colloids Surf. A: Physicochem. Eng. Asp., 377, 379 (2011)
Caro E, Marce RM, Cormack PAG, Sherrington DC, Borrull F, J. Chromatogr. A, 1047, 175 (2004)
Zahedi P, Rezaeian I, Jafari SH, Karami Z, Macromol. Res., 21(6), 649 (2013)
Nguyen LTH, Liao S, Chan CK, Ramakrishna S, . Biomat. Sci.-Polym. E., 23, 1771 (2012)
Manesh ME, Javanbakht M, Atyabi F, Mohammadi A, Mohammadi S, Adergani BA, Dinarvand R, Mat. Sci. Eng. C-Mater., 31, 1692 (2011)
Abdouss M, Asadi E, Deilami SA, mohammadi NB, Aslanzadeh SA, J. Mater. Sci. -Mater. Med., 22, 2273 (2011)
Hiratani H, Fujiwara A, Tamiya Y, Mizutani Y, Lorenzo CA, Biomaterials, 26, 1293 (2005)
Malaekeh-Nikouei B, Ghaeni FA, Motamedshariaty VS, Mohajeri SA, J. Appl. Polym. Sci., 126(1), 387 (2012)
Lu XF, Shi YF, Lv HL, Fu YY, Ma D, Xue W, J. Mater. Sci. -Mater. Med., 25, 1461 (2014)
Cirillo G, Curcio M, Parisi OI, Puoci F, Iemma F, Spizzirri UG, Restuccia D, Picci N, Food Chem., 125, 1058 (2011)
Mohebali A, Abdouss M, Mazinani S, Zahedi P, Polym. Adv. Technol., 27, 1164 (2016)
Zhang L, Guo Y, Chi WH, Shi HG, Ren HQ, Guo TY, Chin. J. Polym. Sci., 32, 1469 (2014)
Hickey T, Kreutzer D, Burgess DJ, Moussy F, J. Biomed. Mater. Res., 61, 180 (2002)
Miura C, Matsunaga H, Haginaka J, J. Pharmaceut. Biomed., 127, 32 (2016)
Nakamura Y, Matsunaga H, Haginaka J, J. Sep. Sci., 39, 1542 (2016)
Zamani M, Morshed M, Varshosaz J, Jannesari M, Eur. J. Pharm. Biopharm., 75, 179 (2010)
