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Received February 28, 2020
Accepted May 13, 2020
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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In-situ crystallization of sildenafil during ionic crosslinking of alginate granules
Department of Chemical Engineering and Materials Science, Chung-Ang University, 221 Heukseok-dong, Dongjak-gu, Seoul 06974, Korea 1Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Sungbuk-gu, Seoul 02841, Korea
jong@cau.ac.kr
Korean Journal of Chemical Engineering, October 2020, 37(10), 1726-1731(6), 10.1007/s11814-020-0580-8
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Abstract
Hydrogel particles containing drug crystals were investigated for the development of drug formulations with improved processability, bioavailability, and physical stability. However, crystal engineering inside hydrogel particles has been limited due to various difficulties involved in the preparation processes and their control. This study demonstrates the crosslinking of alginate granules and the simultaneous crystallization of a drug, sildenafil, inside the granules by using a simple and scalable preparation technique. The particle size of the drug crystals was successfully decreased to the submicron range while their crystallinity could be controlled by the processing parameters. Moreover, these results are shown to be due to the strong interactions between the polymer chains and the drug as well as the diffusion-limited processes of solvent, antisolvent, sildenafil, alginate, and crosslinking ions (Ca2+). This simple crystallization technique will be useful for the development of novel drug delivery systems based on hydrogels and drug crystallites.
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Chung NO, Lee MK, Lee J, Int. J. Pharm., 437, 42 (2012)
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Lee MK, Kim MY, KimS, Lee J, J. Pharm. Sci., 98, 4808 (2009)
Kim S, Lee J, Int. J. Pharm., 397, 218 (2010)
Chin WWL, Parmentier J, Widzinski M, Tan EH, Gokhale R, J. Pharm. Sci., 103, 2980 (2014)
Poornachary SK, Han G, Kwek JW, Chow PS, Tan RB, Cryst. Growth Des., 16, 749 (2016)
Lopez-Mejias V, Knight JL, Brooks CL, Matzger AJ, Langmuir, 27(12), 7575 (2011)
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Lee MK, Lee H, Kim IW, Lee J, Die Pharmazie, 66, 766 (2011)
Choi H, Lee H, Lee MK, Lee J, J. Pharm. Sci., 101, 2941 (2012)
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Favre E, Leonard M, Laurent A, Dellacherie E, Colloids Surf. A: Physicochem. Eng. Asp., 194, 197 (2001)
Song RQ, Colfen H, Adv. Mater., 22(12), 1301 (2010)
Lee H, Lee J, J. Ind. Eng. Chem., 21, 1183 (2015)
Takeuchi H, Yasuji T, Yamamoto H, Kawashima Y, Pharm. Dev. Technol., 5, 355 (2000)
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