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Received March 14, 2020
Accepted May 27, 2020
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Effect of molecular weight of regenerated silk fibroin on silk-based spheres for drug delivery
School of Materials Science and Engineering and Institute for Advanced Materials, Jiangsu University, Zhenjiang, 212013, China 1Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark
liul@ujs.edu.cn
Korean Journal of Chemical Engineering, October 2020, 37(10), 1732-1742(11), 10.1007/s11814-020-0591-5
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Abstract
Silk fibroin presents a good advantage as a drug carrier for drug delivery, due to the excellent biocompatibility, biodegradability and tunable drug loading and release properties. In this work, we constructed silk spheres by phase separation of the regenerated silk fibroin (RSF) solutions with different MW and polyvinyl alcohol; and it was revealed that MW of RSF can affect the structure, size, surface potential and drug loading and release efficiency of silk spheres. Silk spheres prepared from high MW of RSF were found to load more macromolecular drug with negative charge compared to middle and low MW of RSF. However, for the positive charge and low MW drug, the silk spheres prepared from low MW of RSF could present a high loading efficiency compared to other carriers. Finally, a positive drug with low MW, streptomycin was encapsulated in silk spheres prepared from low MW of RSF, and displayed a long bactericidal and bacteriostatic effect compared to bared streptomycin solution. The results obtained provide guidelines for the modification and options of drug transport vehicles for more efficient drug delivery and utilization through a simple, rapidly constructed, applicable and low-cost drug carrier.
Keywords
References
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Liu L, Tian X, Ma Y, Duan Y, Zhao X, Pan G, Angew. Chem.-Int. Edit., 57, 7878 (2018)
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Vepari C, Kaplan DL, Prog. Polym. Sci., 32, 991 (2007)
Kwon KJ, Seok H, Appl. Sci., 8, 1214 (2018)
Kapoor S, Kundu SC, Acta Biomater., 31, 17 (2016)
Pham DT, Saelim N, Tiyaboonchai W, Drug Deliv. Transl. Res., 10, 1 (2019)
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Shi P, Goh JCH, Int. J. Pharm., 420, 282 (2011)
Wu J, Zheng Z, Li G, Kaplan DL, Wang X, Acta Biomater., 39, 156 (2016)
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Champion JA, Katare YK, Mitragotri S, J. Control. Release, 121, 3 (2007)
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Ta HT, Truong NP, Whittaker AK, Davis TP, Peter K, Expert Opin. Drug Deliv., 15, 33 (2018)
Mehrabadi M, Ku DN, Aidun CK, Phys. Rev. E, 93, 023109 (2016)
Hoet PHM, Bruske-Hohlfeld I, Salata OV, J. Nanobiotechnol., 2, 12 (2004)
Mundargi RC, Babu VR, Rangaswamy V, Patel P, Aminabhavi TM, J. Control. Release, 125, 193 (2008)
Tabatabai AP, Partlow BP, Raia NR, Kaplan DL, Blair DL, Langmuir, 34(50), 15383 (2018)
Kim HH, Song DW, Kim MJ, Ryu SJ, Um IC, Ki CS, Park YH, Polymer, 90, 26 (2016)
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Wu JB, Zheng ZZ, Li G, Kaplan DL, Wang XQ, Acta Biomater., 39, 156 (2016)
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Wang J, Yin Z, Xiang X, Kundu SC, Mo X, Lu S, Int. J. Mol. Sci., 17, 2012 (2016)
Cheerarot O, Baimark Y, E-Polymers, 15, 67 (2015)
Kim SY, Naskar D, Kundu SC, Bishop DP, Doble PA, Boddy AV, Chan HK, Wall IB, Chrzanowski W, Sci. Rep., 5, 11878 (2015)
Breslauer DN, Muller SJ, Lee LP, Biomacromolecules, 11(3), 643 (2010)
Lammel AS, Hu X, Park SH, Kaplan DL, Scheibel TR, Biomaterials, 31, 4583 (2010)
Wenk E, Wandrey A, Merkle H, Meinel L, J. Control. Release, 132, 26 (2008)
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Baker MI, Walsh SP, Schwartz Z, Boyan BD, J. Biomed. Mater. Res. B Appl. Biomater., 100B, 1451 (2012)
Shi PJ, Goh JCH, Powder Technol., 215-216, 85 (2012)
Baimark Y, Srihanam P, Srisuwan Y, Phinyocheep P, J. Appl. Polym. Sci., 118(2), 1127 (2010)
Chen M, Shao Z, Chen X, J. Biomed. Mater. Res. Part A, 100A, 203 (2012)
Arifin DY, Lee LY, Wang CH, Adv. Drug Deliv. Rev., 58, 1274 (2006)
Li YJ, University S, Supervision FQ, Center T, Agriculture MO, Food Industry, 357, 1565 (2008)
Tanaka T, Suzuki M, Kuranuki N, Tanigami T, Yamaura K, Polym. Int., 42, 107 (1997)
Tanaka T, Tanigami T, Yamaura K, Polym. Int., 45, 175 (1998)
Chen X, Shao Z, Marinkovic NS, Miller LM, Zhou P, Chance MR, Biophys. Chem., 89, 25 (2001)
Sonoyama M, Nakano T, Appl. Spectrosc., 54, 968 (2016)
Hu X, Kaplan D, Cebe P, Macromolecules, 39(18), 6161 (2006)
Kaszuba M, Corbett J, Watson FM, Jones A, Philos. Trans. R. Soc. Lond. Ser. A-Math. Phys. Eng. Sci., 368, 4439 (2010)
Panyam J, Williams D, Dash A, Leslie-Pelecky D, Labhasetwar V, J. Pharm. Sci., 93, 1804 (2004)
Sawant SB, Joshi JB, Sikdar SK, Biotechnol. Tech., 2, 41 (1988)
Gunduz U, Bioseparation, 9, 277 (2000)
Yoshimizu H, Asakura T, J. Appl. Polym. Sci., 40, 1745 (1990)
Siepmann J, Peppas NA, Adv. Drug Deliv. Rev., 48, 139 (2001)
Siepmann J, Siepmann F, Int. J. Pharm., 364, 328 (2008)
Zhang J, Feng YH, Mi JL, Shen YT, Tu ZG, Liu L, J. Hazard. Mater., 342, 121 (2018)
Chen Q, Zhang L, Feng Y, Shi F, Wang Y, Wang P, Liu L, J. Mat. Chem. B, 6, 7643 (2018)
Feng Y, Liu L, Zhang J, Aslan H, Dong M, J. Mat. Chem. B, 5, 8631 (2017)
Feng Y, Chen Q, Yin Q, Pan G, Tu Z, Liu L, ACS Appl. Bio Mater., 2, 747 (2019)
Mcenery ET, Sweany HC, Turner GC, Ill. Med. J., 4, 15 (1950)
Omar MA, Hammad MA, Nagy DM, Aly AA, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 136, 1760 (2015)
Savidge TA, Biotechnology of industrial antibiotics, Marcel Dekker Inc., New York (1984).
Nori L, ManiKiran SS, Rao N, Int. J. PharmTech Res., 2, 2506 (2010)
