Natural deep eutectic solvents (NADESs) as green solvents have substantial potential for enhancing the solubility of pharmaceuticals in aqueous solutions. In this work, the solubility of two B vitamins (nicotinic acid and 4aminobenzoic acid) in aqueous solutions of two NADESs was measured at temperatures between 298.15 K and 313.15 K and different concentrations of NADESs. The studied NADESs were prepared by mixing dried choline chloride with urea or malonic acid with molar ratios of 1 : 2 and 1 : 1, respectively. Based on the results, chloride+malonic acid was more effective on the solubility of the pharmaceuticals in aqueous solutions. Furthermore, the DESs increased the aqueous solubility of 4aminobenzoic acid more than that of nicotinic acid. The experimental solubility data were modeled with the van Laar activity model as well as the modified Apelblat equation to correlate the solubility of the pharmaceuticals to the temperature and NADESs concentration. The molar enthalpy of dissolution (Δhd) and the molar enthalpy of mixing (Δhmix) of the pharmaceuticals in the aqueous solutions of the NADESs were calculated. These parameters showed that all the dissolution processes were endothermic, while the mixing process as a part of the dissolution process was exothermic.

Nicotinic Acid 4aminobenzoic Acid Deep Eutectic Solvent Solubility Van Laar Modified Apelblat

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