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Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received October 2, 2019
Accepted November 19, 2019

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Selectivity of cholesterol-imprinted system on self-assembled monolayer

Min Jae Shin Young Jae Shin^1†

Department of Cosmetics and Biotechnology, Semyung University, Jecheon, Chungbuk 27136, Korea ¹Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973, USA

Korean Journal of Chemical Engineering, February 2020, 37(2), 290-294(5), 10.1007/s11814-019-0434-4

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Abstract

Molecular imprinting was conducted on a thin polymeric membrane stacked on the self-assembled monolayer of a gold plate. The covalent bonding method was used in the molecular imprinting process. Cholesterol was used as a target molecule. Coating with poly(methyl methacrylate) was followed by hydrolysis and extraction of cholesterol. The remaining site was used to recognize cholesterol. Using the cholesterol-imprinted gold electrode as a working electrode, the cholesterol recognition ability was estimated. Various cholesterol analogs were used to obtain the comparative data to determine the imprinting and selectivity factors. The results showed that molecular similarity was important to enhance the recognition. However, the presence of a hydroxyl functional group played a key role in enhancing the molecular recognition, suggesting that molecular polarity and hydrophobicity are important factors.

Keywords

Sensor Molecular Imprinting Polymer Cholesterol Self-assembled Monolayer

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