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Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received March 15, 2021
Accepted May 18, 2021

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ultrasonic cavitation bubble- and gas bubble-assisted adsorptionof paclitaxel from Taxus chinensis onto Sylopute

Da-Yeon Kang Jin-Hyun Kim^†

Department of Chemical Engineering, Kongju National University, Cheonan 31080, Korea

Korean Journal of Chemical Engineering, November 2021, 38(11), 2286-2293(8), 10.1007/s11814-021-0852-y

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Abstract

This study presents a technique for adsorption of paclitaxel on Sylopute using ultrasonic cavitation bubbles and gas bubbles. Compared with the conventional adsorption (control), the adsorbed amount and adsorption rate constant increased, respectively, by 1.27-1.44 times and 7.44-9.71 times in ultrasonic adsorption (with mixing at 80-250W), 1.14-1.27 times and 4.63-9.31 times in ultrasonic adsorption (without mixing at 80-250 W), and 1.06-1.19 times and 1.18-1.34 times in gas bubble-adsorption (without mixing at 1.15-9.41 L/min). As a result of investigating the adsorption mechanism in which cavitation bubbles were introduced, it was shown that microjets and shock waves produced by bubble collapse, rather than the bubble itself, drastically improve mass transport in the pores of the adsorbent, thereby completely eliminating intraparticle diffusion resistance. In the case of gas bubbles, although the intraparticle diffusion coefficient increased by 1.34-1.75 times compared with the control, there was a limitation in promoting intraparticle diffusion.

Keywords

Paclitaxel Adsorption Ultrasonic Cavitation Bubble Gas Bubble Mechanism

References

Kang HJ, Kim JH, Biotechnol. Bioprocess Eng., 25, 86 (2020)
Seca AML, Pinto DCGA, Int. J. Mol. Sci., 19, 263 (2018)
Kang HJ, Kim JH, Korean J. Chem. Eng., 36(12), 1965 (2019)
Pyo SH, Choi HJ, Han BH, J. Chromatogr. A, 1123, 15 (2006)
Seo HW, Kim JH, Process Biochem., 87, 238 (2019)
Pyo SH, Park HB, Song BK, Han BH, Kim JH, Process Biochem., 39(12), 1985 (2004)
Yoo KW, Kim JH, Biotechnol. Bioprocess Eng., 23, 532 (2018)
Lee CG, Kim JH, Korean Chem. Eng. Res., 54(1), 89 (2016)
Lim YS, Kim JH, J. Chem. Thermodyn., 115, 261 (2017)
Hamdaoui O, Naffrechoux E, Tifouti L, Petrier C, Ultrason. Sonochem., 10, 109 (2003)
Hamdaoui O, Naffrechoux E, Ultrason. Sonochem., 16, 15 (2009)
Schueller BS, Yang RT, Ind. Eng. Chem. Res., 40(22), 4912 (2001)
Zhou X, Jing G, Lv B, Zhou Z, Zhu R, Chemosphere, 160, 332 (2016)
Lee JY, Kim JH, Sep. Purif. Technol., 103, 8 (2013)
Kim HS, Kim JH, Process Biochem., 56, 163 (2017)
Maneechakr P, Karnjanakom S, J. Chem. Thermodyn., 106, 104 (2017)
Cho DN, Kim JH, Korean Chem. Eng. Res., 58(1), 127 (2020)
Park SH, Kim JH, Korean Chem. Eng. Res., 58(1), 113 (2020)
Hamdaoui O, Chiha M, Naffrechoux E, Ultrason. Sonochem., 15, 799 (2008)
Wu FC, Tseng RL, Juang RS, J. Colloid Interface Sci., 283(1), 49 (2005)
Kim YS, Kim JH, J. Chem. Thermodyn., 130, 104 (2019)
Ondarts M, Reinert L, Guittonneau S, Baup S, Delpeux S, Leveque JM, Duclaux L, Chem. Eng. J., 343, 163 (2018)
Ji JB, Lu XH, Xu ZC, Ultrason. Sonochem., 13, 463 (2006)
Kang HJ, Kim JH, Biotechnol. Bioprocess Eng., 24, 513 (2019)
Shin HS, Kim JH, Process Biochem., 51(7), 917 (2016)
Wolloch L, Kost J, J. Control. Release, 148, 204 (2010)
Wohgemuth K, Kordylla A, Ruether F, Schembecker G, Chem. Eng. Sci., 64(19), 4155 (2009)
Krishna R, Ellenberger J, Urseanu MI, Keil FJ, Naturwissenschaften, 87, 455 (2000)