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Received February 7, 2021
Accepted April 11, 2021
- This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Optimization of preparation and properties of Gardenia yellow pigment-loaded alginate beads
1School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, China 2School of Light Industry and Chemical Engineering, Guangdong University of Technology, Guangzhou, China
Korean Journal of Chemical Engineering, August 2021, 38(8), 1669-1675(7), 10.1007/s11814-021-0807-3
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Abstract
Gardenia yellow pigment (GYP) loaded alginate beads were prepared by the ionic gelation technique, and the preparation parameters were optimized by response surface methodology for high encapsulation efficiency. The optimized parameters were alginate concentration of 3.3%, CaCl2 concentration of 2.4%, and GYP concentration of 3.2mg/mL, under which the encapsulation efficiency was 73.61%. The surface morphology and bead size analysis showed that the GYP-loaded alginate beads had a roughly spherical morphology with a wrinkled surface, and their average diameter was 0.87 mm. In vitro release test revealed that the GYP release had a pH-dependent release profile and a two-step release process. The Rigter-Peppas model was the most proper model to assess the GYP release from alginate beads. The release mechanism of GYP at pH 1.2 and 7.4 was non-Fickian transport and case-II transport, respectively. The 2,2-diphenyl-1-picrylhydrazyl assay indicated that the encapsulated GYP had effectively maintained 82.56% of the antioxidant activity.
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Chen Q, Xue G, Ni Q, Wang Y, Gao Q, Zhang Y, Xu G, Food Sci. Nutr., 8, 1 (2020)
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Olayemi OJ, Apeji YE, Isimi CY, J. Pharm. Innov. (2020), https://doi.org/10.1007/s12247-020-09509-2.
Yin ZC, Wang YL, Wang K, J. Drug Deliv. Sci. Technol., 43, 12 (2018)
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Kim H, Fassihi R, Pharm. Res., 14, 1415 (1997)