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Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received June 15, 2021
Accepted September 14, 2021

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Negative pressure cavitation fractional precipitation for the purification of paclitaxel from Taxus chinensis

Hye-Su Min Jin-Hyun Kim^†

Department of Chemical Engineering, Kongju National University, Cheonan 31080, Korea

Korean Journal of Chemical Engineering, January 2022, 39(1), 58-62(5), 10.1007/s11814-021-0959-1

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Abstract

The precipitation efficiency of paclitaxel from Taxus chinensis was remarkably improved through negative pressure cavitation fractional precipitation. When paclitaxel was precipitated under a negative pressure of -200mmHg, almost all of the paclitaxel (>97%) could be recovered in a short operation time (1min). The precipitation rate constant was calculated using the JMAK equation for kinetic analysis. The rate constant in the case of negative pressure (- 50 to -200mmHg) cavitation fractional precipitation increased by 2.147-6.046 times compared to fractional precipitation without negative pressure. The change of activation energy by the negative pressure (-50 to -200mmHg) was also calculated using the Arrhenius equation. The activation energy changes were -1,767 to -4,161 J/mol, implying that the activation energy could be reduced by introducing negative pressure, resulting in an increased precipitation rate. In addition, the application of negative pressure reduced the size of the precipitate by 3.3 times and increased the diffusion coefficient of paclitaxel by 4.4 times.

Keywords

Paclitaxel Fractional Precipitation Negative Pressure Cavitation Kinetics

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