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- In relation to this article, we declare that there is no conflict of interest.
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Received April 13, 2022
Accepted June 10, 2022
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Ultrasonic cavitation bubble- and gas bubble-assisted fractional precipitation for the purification of (+)-dihydromyricetin
Center for Future Sustainable Technology, Department of Chemical Engineering, Kongju National University, Cheonan 31080, Korea
Korean Journal of Chemical Engineering, November 2022, 39(11), 3067-3073(7), 10.1007/s11814-022-1202-4
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Abstract
This study presents the ultrasonic cavitation bubble- and gas bubble-assisted fractional precipitation that dramatically improves the precipitation efficiency in existing precipitation method for purifying (+)-dihydromyricetin. Compared to the conventional method, the time required for precipitation was reduced by 40 times. The particle size was reduced by 4.0-7.4 times and 3.7-4.4 times for cavitation bubbles and gas bubbles, respectively, and the diffusion coefficient was increased by 5.1-9.2 times (cavitation bubble) and 3.7-4.4 times (gas bubble). Meanwhile, the precipitation rate constant was increased by 11.0-65.0 times and 17.0-24.6 times and the activation energy was decreased by -5,543~-9,655 J/mol and -6,546~-7,404 J/mol, which resulted in an improved precipitation rate. The results of the thermodynamic analysis showed that the precipitation was exothermic and non-spontaneous.
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References
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Kang HJ, Kim JH, Process Biochem., 99, 316 (2020)
Lee CG, Kim JH, Process Biochem., 59, 216 (2017)
Park JN, Kim JH, Process Biochem., 53, 224 (2017)
Wohlgemuth K, Ruether F, Schembecker G, Chem. Eng. Sci., 65, 1016 (2010)
Min HS, Kim JH, Korean J. Chem. Eng., 39, 58 (2022)
Wohlgemuth K, Kordylla A, Ruether F, Schembecker G, Chem. Eng. Sci., 64, 4155 (2009)
Guo Z, Zhang M, Li H, Wang J, Kougoulos E, J. Cryst. Growth, 273, 555 (2005)
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Kim MJ, Kim JH, Korean Chem. Eng. Res., 54, 278 (2016)
Ma D, Marshall JS, Wu J, J. Acoust. Soc. Am., 114, 3496 (2018)
Guo Z, Jones AG, Li N, Chem. Eng. Sci., 61, 1617 (2008)
Wolloch L, Kost J, J. Control. Release, 148, 204 (2010)
Yoon TH, Kim JH, Biotechnol. Bioprocess Eng., 25, 777 (2020)
Petrou AL, Terzidaki A, Chem. Geol., 381, 144 (2014)
