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Received July 3, 2022
Accepted August 17, 2022
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Process synthesis and optimization for the isolation and purification of paclitaxel from Taxus chinensis
Center for Future Sustainable Technology, Department of Chemical Engineering, Kongju National University, Cheonan 31080, Korea
Korean Journal of Chemical Engineering, December 2022, 39(12), 3389-3398(10), 10.1007/s11814-022-1261-6
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Abstract
Cavitation extraction, water/hexane washing, and cavitation precipitation-based process synthesis and optimization were performed for the isolation and purification of biomass-derived paclitaxel. The final purity, overall yield, and operating time were significantly improved when negative pressure cavitation extraction was followed by sequential washing with water and hexane, adsorbent treatment, and negative pressure cavitation fractional precipitation using acetone-pentane and methanol-water. This procedure showed a purity and yield increase of 11.0-45.6% and 2.2-29.6%, respectively, and an operating time reduction of 56.2-98.3% compared to the traditional methods.
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References
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