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Received April 18, 2022
Accepted July 3, 2022
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Synthesis of fluorescent dye-embedded silica nanoparticles for vitamin D3 detection using sandwich-like assay
1Department of Chemical Engineering, Division of Chemical and Biological Engineering, Kangwon National University, Gangwon-do 24341, Korea 2Division of Mechanical & Biomedical, Mechatronics and Materials Science and Engineering, Kangwon National University, Gangwon-do 24341, Korea 3Department of Research and Development, Cantis Inc., Ansan-si, Gyeonggi-do 15588, Korea
khmhlee@kangwon.ac.kr
Korean Journal of Chemical Engineering, December 2022, 39(12), 3473-3481(9), 10.1007/s11814-022-1221-1
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Abstract
This study devised and examined a sandwich-like assay for detecting vitamin D3 dissolved in acetonitrile using fluorescent dye-embedded silica nanoparticles (AF647@SiNPs). First, AF647@SiNPs were synthesized via the modified Stober method to embed the fluorescent dye molecules in the silicate network. Then, vitamin D3 (sample) was immobilized using an azide linker on the magnetic nanoparticles (MNPs). The immobilized vitamin D3 reacted with the antibody immobilized on the surface of AF647@SiNPs (Anti-VD3@AF647@SiNPs). The vitamin D3 concentration was calculated back using the fluorescence of the remaining unreacted Anti-VD3@AF647@SiNPs. Finally, we examined how applying conditions of AF647@SiNPs influenced the measurement reliability: (1) the initial loading of AF647@SiNPs; (2) the antibody-labeling degree of AF647@SiNPs.
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Ow H, Larson DR, Srivastava M, Baird BA, Webb WW, Wiesner U, Nano Lett., 5(1), 113 (2005)
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