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Received August 12, 2021
Accepted September 7, 2021
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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An effective method for cysteine determination based on fluorescence resonance energy system between co-doped graphene quantum dots and silver nanoparticles
Department of Chemical and Biological Engineering, Gachon University, Seongnam 13120, Korea
psj@gachon.ac.kr
Korean Journal of Chemical Engineering, April 2022, 39(4), 1065-1071(7), 10.1007/s11814-021-0956-4
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Abstract
Cysteine (Cys) is a crucial amino acid. Developing a method for Cys evaluation and detection is necessary for the diagnosis of various diseases. A variety of sensors use graphene quantum dots (GQDs) for biological compound determination; however, GQDs demonstrate very poor fluorescence quantum yield. Therefore, we doped nitrogen and phosphorus into GQDs to form composite material NP-GQDs with enhanced fluorescence properties. NPGQDs were characterized by ultraviolet-visible, fluorescence spectroscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. Then, we used NP-GQDs as donors and silver nanoparticles (AgNPs) as acceptors to design a fluorescence resonance energy transfer (FRET) system for Cys detection. Optimal conditions for sensing were investigated, and under these conditions our FRET system showed good results in Cys determination. The fluorescence intensity of NP-GQDs was quenched proportionally along with increasing Cys concentration from 0.5 to 4.5 μM and the limit of detection (LOD) was 0.1 μM. In the presence of different amino acids, the FRET system also showed excellent selectivity for the Cys detection.
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References
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Xie XX, Yin CX, Yue YK, Huo FJ, Sens. Actuators B-Chem., 267, 76 (2018)
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Xie YT, Zheng JX, Wang YL, Wan JL, Yang YZ, Liu XG, Chen YK, Nanotechnology, 30, 10 (2019)
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Jiang HS, Zhang Y, Lu ZW, Lebrun R, Gontero B, Li W, Small, 15, e1900860 (2019)
López-Lorente AI, Soriano ML, Valcárcel M, Microchim. Acta, 181, 1789 (2014)
Gakiya-Teruya M, Palomino-Marcelo L, Rodriguez-Reyes JCF, Methods Protoc., 2, 3 (2019)
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Xu Y, Wu M, Liu Y, Feng XZ, Yin XB, He XW, Zhang YK, Chem.-Eur. J., 19, 2276 (2013)
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Wang WJ, Peng JW, Li FM, Su BY, Chen X, Chen XM, Microchim. Acta, 186, 32 (2019)
Qu D, Sun ZC, Zheng M, Li J, Zhang YQ, Zhang GQ, Zhao HF, Liu XY, Xie ZG, Adv. Opt. Mater., 3, 360 (2015)
Aryal S, Bahadur KCR, Bhattarai N, Kim CK, Kim HY, J. Colloid Interface Sci., 299, 189 (2006)
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Vladislavic N, Roncevic IS, Buzuk M, Buljac M, Drventic I, J. Solid State Electrochem., 25, 841 (2021)
