Crystallization is often carried out in batch stirred vessels. However, it is difficult to obtain uniform crystal size distribution (CSD), as it strongly depends on prevailing flow field operating conditions. This is adversely affected by the geometry of stirred vessels. Hence in this work, CFD simulations were performed to investigate flow field, mixing and crystallization phenomena in a stirred vessel. The performance of the stirred vessel was compared with draft tube baffled stirred vessel. The flow field was quantified through liquid circulation and vorticity. The mixing was analyzed through macromixing time in the stirred vessel. The solubility data, nucleation, and growth kinetics were integrated with CFD through a user-defined function (UDF) to predict crystallization phenomena. The predicted results were validated with experimental data available in the literature. The effects of seed mass, size and temperature on CSD were investigated and optimum conditions [750 gm (seed mass); 500 μm (seed size); 308 K (temperature)] for favourable crystal growth were identified. The performance of the proposed baffled stirred vessel was found to be significant, and it supports enhancing flow field, mixing and crystallization process.

Hydrodynamics Mixing Crystal Growth Nucleation CFD Population Balance Model

Su Q, Nagy ZK, Rielly CD, Chem. Eng. Process., 89, 41 (2015)
Gao Z, Rohani S, Gong J, Wang J, Engineering, 3, 343 (2017)
Ali H, Solsvik J, Phys. Fluids, 33, 033319 (2021)
Mendoza-Escamilla VX, Alonzo-García A, Mollinedo HR, González-Neria I, Yáñez-Varela JA, Martinez-Delgadillo SA, Chin. J. Chem. Eng., 26, 942 (2018)
Steiros K, Bruce PJK, Buxton ORH, Vassilicos JC, Springer Proc. in Phys., 363 (2016).
Paul EL, Midler M, Sun Y, Handb. Ind. Mix., 1027 (2004)
Başbuğ S, Papadakis G, Vassilicos JC, Phys. Rev. Fluids, 3, 084502 (2018)
Yoon HS, Balachandar S, Ha MY, Phys. Fluids, 21, 085102 (2009)
Steiros K, Bruce PJK, Buxton ORH, Vassilicos JC, Phys. Rev. Fluids, 2, 094802 (2017)
Wendt JF, Anderson JD, Degroote J, Degrez G, Dick E, Grundmann R, Vierendeels J, Computational fluid dynamics: An introduction, Springer Sci, & Business Media (2008).
Li X, Zhao H, Zhang Z, Liu Y, Zhang T, Chin. J. Chem. Eng., 29, 57 (2021)
Pukkella AK, Vysyaraju R, Tammishetti V, Rai B, Subramanian S, Chem. Eng. J., 358, 621 (2019)
Wang L, Tian Y, Qi Y, Gao Y, Wang M, Particuology, 56, 91 (2021)
Joshi JB, Nere NK, Rane CV, Murthy BN, Mathpati CS, Patwardhan AW, Ranade VV, Can. J. Chem. Eng., 89, 754 (2011)
Vedantam S, Ranade VV, Sadhana - Acad. Proc. Eng. Sci., 38, 1287 (2013)
Hara S, Ebihara S, Kawaguchi Y, Phys. Fluids, 32, 075102 (2020)
Sulttan S, Rohani S, J. Cryst. Growth, 505, 19 (2019)
Szilágyi B, Nagy ZK, Cryst. Growth Des., 18, 1415 (2018)
de Souza LM, Temmel E, Janiga G, Seidel-Morgenstern A, Thévenin D, Chem. Eng. Sci., 232, 116344 (2021)
Rohani S, Horne S, Murthy K, Org. Process Res. Dev., 9, 858 (2005)
Temmel E, Eicke M, Lorenz H, Seidel-Morgenstern A, Cryst. Growth Des., 16, 6756 (2016)
Green D, Handb. Ind. Cryst., 181 (2002)
Doki N, Kubota N, Sato A, Yokota M, Hamada O, Masumi F, AIChE J., 45, 2527 (1999)
Lenka M, Sarkar D, J. Cryst. Growth, 486, 130 (2018)
Doki N, Kubota N, Yokota M, Chianese A, J. Chem. Eng. Jpn., 35, 670 (2002)
Bohlin M, Rasmuson AC, Can. J. Chem. Eng., 70, 120 (1992)
Doki N, Kubota N, Sato A, Yokota M, Chem. Eng. J., 81, 313 (2001)
Wei H, Zhou W, Garside J, Ind. Eng. Chem. Res., 40, 5255 (2001)
Wang Z, Mao Z, Yang C, Shen X, Chin. J. Chem. Eng., 14, 713 (2006)
Trampuž M, Teslić D, Likozar B, Chem. Eng. Res. Des., 165, 254 (2021)
Green DA, Handb. Ind. Cryst., 290 (2019)
Kumaresan T, Joshi JB, Chem. Eng. J., 115, 173 (2006)
Ali BA, Janiga G, Temmel E, Seidel-Morgenstern A, Thévenin D, J. Cryst. Growth, 372, 219 (2013)
Temmel E, Eisenschmidt H, Lorenz H, Sundmacher K, Seidel-Morgenstern A, Cryst. Growth Des., 16, 6743 (2016)
Lewis A, Seckler M, Kramer H, Van Rosmalen G, Industrial Crystallization: Fundamentals and Applications (Cambridge University Press, 2015).
Domínguez-Vázquez D, Jacobs GB, Tartakovsky DM, Phys. Fluids, 33, 033326 (2021)
Galletti C, Paglianti A, Lee KC, Yianneskis M, AIChE J., 50, 2050 (2004)
Ding J, Gidaspow D, AIChE J., 36, 523 (1990)
Mersmann A, Crystallization technology handbook, CRC press, Florida (2001).
McGraw R, Aerosol Sci. Technol., 27, 255 (1997)
Hemalatha K, Rani KY, Ind. Eng. Chem. Res., 56, 6012 (2017)
John V, Angelov I, Öncül AA, Thévenin D, Chem. Eng. Sci., 62, 2890 (2007)
Fox RW, Pritchard PJ, Mcdonald AT, Introduction to fluid mechanics, 7Th Ed., Wiley India Pvt. Limited (2009).
Marshall EM, Bakker A, Handb. Ind. Mix., 257 (2001)
Ali BA, Börner M, Peglow M, Janiga G, Seidel-Morgenstern A, Thévenin D, Cryst. Growth Des., 15, 145 (2015)