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Received July 27, 2021
Accepted February 20, 2022
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Solubility and crystallization of ibuprofen in the presence of solvents and antisolvents
SK Innovation R&D Institute, Expo-ro, Yuseong-gu, Daejeon 34124, Korea 1Department of Chemical Engineering, Kyungpook National University, Daegu 41566, Korea
Korean Journal of Chemical Engineering, June 2022, 39(6), 1549-1556(8), 10.1007/s11814-022-1090-7
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Abstract
The solubility and crystallization behavior of ibuprofen was investigated in the presence of solvents (acetone and ethanol) and antisolvents (water and hydrogen peroxide). The solubility of ibuprofen was determined in the mixtures of acetone+water, acetone+hydrogen peroxide, ethanol+water, and ethanol+hydrogen peroxide. The phase boundaries of these ternary systems were determined as a function of the mixtures’ concentration at 27, 35, and 40℃. Based on the solubility data, ibuprofen was crystallized using the antisolvent crystallization technique. It was found that the external shape and internal structure of ibuprofen crystals were nearly independent of solvent and antisolvent, but the size distribution of the resulting particles changed. In the crystallization process, the application of ultrasound induced a significant reduction in particle size and caused severe agglomeration of micronized ibuprofen. This problem was solved by adding an external additive (Tween 80) to the solvent and antisolvent mixtures.
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Ulker Z, Erkey C, J. Supercrit. Fluids, 120, 310 (2017)
Matsumoto M, Ohno M, Wada Y, Sato T, Okada M, Hiaki T, J. Cryst. Growth, 469, 91 (2017)
Jafari D, Nowee SM, Noie SH, J. Dispersion Sci. Technol., 38, 677 (2017)
Kaialy W, Larhrib H, Chikwanha B, Shojaee S, Nokhodchi A, Int. J. Pharm., 464, 53 (2014)
Castillo-Peinado LS, de Castro MDL, J. Pharm. Pharmacol., 68, 1249 (2016)
Lee J, Ashokkumar M, Kentish SE, Ultrason. Sonochem., 60, 60 (2014)
Ramisetty KA, Pandit AB, Gogate PR, Ind. Eng. Chem. Res., 52, 17573 (2013)
Rainsford KD, Inflammopharmacology, 17, 275 (2009)
Wang S, Song Z, Wang J, Dong Y, Wu M, J. Chem. Eng. Data, 55, 5283 (2010)
Kim HJ, Yeo SD, Chem. Eng. Res. Des., 97, 68 (2015)
Park SJ, Yeo SD, Sep. Sci. Technol., 42, 2645 (2007)
Yeo SD, Kim MS, Lee JC, J. Supercrit. Fluids, 25, 143 (2003)
