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- In relation to this article, we declare that there is no conflict of interest.
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Received August 30, 2022
Accepted November 28, 2022
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Biodegradable dexamethasone polymer capsule for long-term release
Department of Chemical & Environmental Engineering, University of Cincinnati, 9643 Waterford Pl, Loveland, OH 45140, USA 1Department of Otolaryngology, College of Medicine, University of Cincinnati, 9643 Waterford Pl, Loveland, OH 45140, USA
Korean Journal of Chemical Engineering, February 2023, 40(2), 452-460(9), 10.1007/s11814-022-1358-y
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Abstract
We have developed sustained Dex (dexamethasone) capsule implants for sustained local delivery for inflammatory disease treatment. Four different biodegradable polymers were used as capsule materials: polycaprolactone (PCL), poly(lactic acid) (PLA), 90 : 10 poly(lactic-co-glycolide) (PLGA), and 50 : 50 PLGA. The drug release profiles from the four types of capsule were compared and the profiles were fit to a cylindrical reservoir first-order kinetics model. As a result, 50 : 50 PLGA showed the fastest release with the largest permeability and partition coefficient at 0.4909 nm/s and 1.9519, respectively. On the other hand, PCL showed the slowest release with the smallest permeability and partition coefficient at 0.1915 nm/s and 0.8872, respectively. The results indicate that the drug release kinetics are highly correlated with hydrophobicity of the polymer sheet: the more hydrophobic, the slower the drug release kinetics for the hydrophilic drug. The in vitro therapeutic efficacy of the Dex implant was also explored using TNF-? stimulated human umbilical vein endothelial cells (HUVECs), showing effective suppression of IL-6 levels with the implant compared to free Dex with minimal toxicity. Overall, this study suggests that the release trend of Dex from implants follows the hydrophobicity of each polymer, and the Dex implant inhibits the IL-6 expression effectively.
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Choi YH, Ahn HJ, Park MR, Han MJ, Lee JH, Kwon SK, Acta. Biomaterialia., 86, 269 (2019)
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Freney EJ, Martin ST, Buseck PR, Aerosol Sci. Technol., 43, 799 (2009)
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Siepmann J, Siepmann F, J. Control. Release, 161, 351 (2011)
Grathwohl P, Diffusion in natural porous media, Springer US: Boston, MA, 43-81 (1998).
Waterkotte T, He X, Wanasathop A, Li SK, Park YC, ACS Biomater. Sci. Eng., 8, 4428 (2022)
Hao HX, Wang JK, Wang YL, J. Chem. Eng. Data, 49, 1697 (2004)
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Garrouch AA, Ali L, Qasem F, Mater. Interfaces, 40, 4363 (2001)
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Wu S, Xu H, Peng J, Wang C, Jin Y, Liu K, Sun H, Qin J, Biochimie, 110, 62 (2015)
Jia Z, Babu PV, Si H, Nallasamy P, Zhu H, Zhen W, Misra HP, Li Y, Liu D, Int. J. Cardiol., 168, 2637 (2013)
Langendorf E, Rommens PM, Drees P, Ritz U, Int. J. Mol. Sci., 22, 7986 (2021)
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