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- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received June 10, 2022
Revised August 11, 2022
Accepted September 1, 2022
- Acknowledgements
- This research was financially supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF-2020R1F1A106966813). This study was also supported by the Soonchunhyang University Research Fund.
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Amorphous solid dispersions of tegoprazan and three different polymers: In vitro/in vivo evaluation of physicochemical properties
1Department of Medical Science, Soonchunhyang University, Asan, Chungnam 31538, Korea 2Department of Pharmaceutical Engineering, Soonchunhyang University, Asan, Chungnam 31538, Korea
guangchoi@gmail.com
Korean Journal of Chemical Engineering, April 2023, 40(4), 986-998(13), 10.1007/s11814-022-1280-3
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Abstract
Polymer-based amorphous solid dispersion (PASD) technology has attracted attention as one of the most
feasible approaches for improving the solubility, dissolution rate, and bioavailability of insoluble drugs. Tegoprazan
(TPZ) is a promising new drug used to treat gastroesophageal reflux disease with poor water solubility (~0.03 mg/mL).
This study developed novel PASD materials containing TPZ. Three polymers were used for this study: PVP, HPMCAS, and carbomer. The PASD powders were prepared via solvent evaporation at 50% drug loading. The physicochemical properties of PASD solids were characterized using PXRD, MDSC, TGA, FT-IR, 1H SS-NMR, and stability
testing. PASD powders fabricated with the neutral polymer PVP showed poor stability against drug crystallization. In
contrast, those prepared using HPMCAS and carbomer showed no signs of crystallization even after three months of
storage at 40oC/75% RH. A correlation between intermolecular interaction and physical stability was inferred for the
TPZ PASD formulations. Amorphization of the crystalline TPZ with HPMCAS and carbomer resulted in a greatly
increased in vitro dissolution rate. These two polymers showed similar performance, eliciting appreciable improvement
in the in vivo absorption tests in rats. In summary, PASD formulations using acidic polymers (HPMCAS and carbomer) are novel formulations for improving the therapeutic effects of TPZ.
Keywords
References
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