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Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received December 27, 2022
Revised January 28, 2023
Accepted January 31, 2023

Acknowledgements: This work was supported by the 2019 Yeungnam University Research Grant

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Utilization of functionalized silane coatings for enhanced mechanical properties of hydroxyapatite filler

Eunhyun Ji^1† Young Hoon Song^2† Jeong Hyun Seo^2† Kye Il Joo^1†

¹Division of Chemical Engineering and Materials Science, Ewha Womans University, Seoul 03760, Korea ²School of Chemical Engineering, Yeungnam University, 280 Daehakro, Gyeongsan, Gyeongbuk 38541, Korea

jhseo78@yu.ac.kr, kijoo@ewha.ac.kr

Korean Journal of Chemical Engineering, July 2023, 40(7), 1709-1714(6), 10.1007/s11814-023-1396-0

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Abstract

Silane coupling agents are widely used as molecular bridges between inorganic minerals and organic materials to modify surface properties for diverse biomedical applications. In this study, we developed hydroxyapatite (HAp)-based scaffolds by fabricating the surface of HAp pellets with silane coupling agents containing methacrylate, amine, and carboxylic acid functional groups to improve their mechanical properties for use as biodegradable fillers in dental and bone regeneration applications. Surface coating with carboxylic acid-functionalized silane exhibited a substantially enhanced mechanical strength of up to 30 MPa, which possibly resulted from the stable configuration of interfacial bonding via electrostatic attractive interaction in the a-planes of the HAp pellets. Furthermore, the functionalized silane-coated HAp scaffolds displayed excellent biocompatibility, which suggests that they could be utilized as bone filler composites for bone tissue engineering.

Keywords

Hydroxyapatite Silane Coupling Molecular Bridge Agglomeration Surface Modification

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