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- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received April 23, 2023
Revised June 12, 2023
Accepted June 14, 2023
- Acknowledgements
- This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (No. 2021R1I1A3054572).
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Rheological and molecular dynamics simulation studies of the gelation of human serum albumin in anionic and cationic surfactants
School of Chemical Engineering, Pusan National University, Busan 46241, Korea
kyuhyun@pusan.ac.kr
Korean Journal of Chemical Engineering, August 2023, 40(8), 1871-1881(11), 10.1007/s11814-023-1513-0
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Abstract
We report the gelation of human serum albumin (HSA) of 5-12 wt% concentrations in 0-0.15 M aqueous
solutions of a cationic surfactant, cetyltrimethylammonium bromide (CTAB), or an anionic surfactant, sodium dodecyl
sulfate (SDS), under isothermal and nonisothermal conditions. Under both conditions, the initial increase in the CTAB
concentration (up to 0.075 M) accelerated HSA gelation (marked by decreasing gel times (tgel) for the isothermal case or
gel temperature (Tgel) for the nonisothermal case), whereas increasing the SDS concentration inhibited HSA gelation
(i.e., increasing tgel or Tgel). The increase and decrease in HSA gelation by CTAB and SDS, respectively, reached a maximum at a surfactant/protein molar ratio of 100. Rheological properties, i.e., storage modulus (G') and loss modulus
(G''), exhibited mechanically stable behavior of HSA/CTAB gels over the covered concentration range, whereas HSA/
SDS gels exhibited decreasing mechanical properties with increasing SDS concentration. Molecular dynamics simulation showed that the greater rate of the unfolding of the HSA structure in CTAB than in SDS was behind the rapid
gelation kinetics of HSA in CTAB compared with SDS. Our result establishes that cationic CTAB and anionic SDS surfactants exert wide-ranging control over the rheological and kinetic properties of HSA hydrogel
Keywords
References
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