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- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
-
Received March 30, 2023
Revised May 16, 2023
Accepted May 22, 2023
- Acknowledgements
- E. J. Lee analyzed the characteristics of HA hydrogels. K. H. Park performed cell culture for the cytotoxicity test of the hydrogels. S.-J. Gwak and Y. B. Lee are the major contributors to writing the manuscript. K.M. Huh and S.-W. Kang supervised the study. All authors have read and approved the final manuscript.
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The use of acetylation to improve the performance of hyaluronic acid-based dermal filler
1Department of Chemical Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Korea 2MECHABIO Group, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Korea 3Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Korea 4Research Group for Biomimetic Advanced Technology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Korea 5Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea 6Human and Environmental Toxicology Program, University of Science and Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Korea
swkang@kitox.re.kr, khuh@cnu.ac.kr
Korean Journal of Chemical Engineering, August 2023, 40(8), 1963-1969(7), 10.1007/s11814-023-1496-x
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Abstract
Injectable dermal fillers, which are used for various plastic surgery purposes, are experiencing explosive market growth due to increasing interest in appearance management. Hyaluronic acid (HA) hydrogels have been considered an ideal material for fillers due to their high-water retention, biodegradability, and biocompatibility. However, their
application is limited by shortcomings in durability and persistence caused by rapid enzymatic degradation. Therefore,
in this study, we introduce acetylated hyaluronic acid-divinyl sulfone (AcHA-DVS) hydrogels for a novel approach for
improving the physical properties and gel retention time of HA. The AcHA-DVS hydrogels showed significant advantages in terms of longevity and performance as dermal fillers compared to HA-DVS hydrogels. These results suggest
that our new AcHA-DVS hydrogel is a promising biomaterial as an injectable filler or scaffold for tissue engineering.
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16. R. Song, M. Murphy, C. Li, K. Ting, C. Soo and Z. Zheng, Drug Des. Dev. Ther., 12, 3117 (2018).
17. K. Bergman, C. Elvingson, J. Hilborn, G. Svensk and T. Bowden,Biomacromolecules, 8, 2190 (2007).
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21. I. Dueramae, M. Yoneyama, N. Shinyashiki, S. Yagihara and R. Kita,Int. J. HeatMass Transf., 132, 997 (2019).
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