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Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received May 18, 2022
Revised June 6, 2023
Accepted June 20, 2023

Acknowledgements: This work was supported by the National Research Foundation of Korea grant funded by the Korean Government (MSIT) (No. 2021R1A2C2006888)

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Synthesis of an antibiotic-preserving antimicrobial tetracycline-loaded gellan gum gel

Gokul Paramasivam^1† Duraisami Dhamodharan² Somasundaram Chandra Kishore³ Hun-Soo Byun^4†

¹Saveetha School of Engineering, Department of Biotechnology, Saveetha Institute of Medical & Technical Sciences (SIMATS), Saveetha Nagar, Thandalam, Chennai 602105, Tamil Nadu, India ²Center for Refining & Advanced Chemicals, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia ³Saveetha School of Engineering, Department of Biomedical Engineering, Saveetha Institute of Medical & Technical Sciences (SIMATS), Saveetha Nagar, Thandalam, Chennai 602105, Tamil Nadu, India ⁴Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu, Jeonnam 59626, South Korea

gokul.parama@gmail.com, hsbyun@jnu.ac.k

Korean Journal of Chemical Engineering, September 2023, 40(9), 2082-2086(5), 10.1007/s11814-023-1517-9

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Abstract

Gels play a significant role in our daily lives as they provide stability and desired features to various items of regular use, such as cosmetics, pharmaceuticals, household items, and agricultural products. However, a microbial attack on gels commonly occurs during gel-based formulations. Antibiotic-loaded gels can reportedly be stored for a long time. In this study, we fabricated a tetracycline-loaded gellan gum (TC/GG) gel and assessed its long-term stability against microbial attack. Morphological analyses revealed a firm and smooth texture with multifold bumpy surfaces on the GG and TC/GG gels. Fourier transform infrared spectroscopic analysis showed that the gel was well hydrated and thus suitable for releasing antibiotics. The feasibility of inhibiting microorganisms was qualitatively examined using the disk diffusion method. Interestingly, the unloaded GG gel itself exhibited an antimicrobial effect, while the loaded TC/GG gel showed a better antibacterial effect on S. aureus than on E. coli. TC/GG can be used to store and protect gels from microbial attacks for a long duration. In addition, it is suitable for storing bioactive agents, which are used in the biomedical field.

Keywords

Gels Gellan Gum Tetracycline Encapsulation Antimicrobial Property E. coli and S. aureus

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