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Non-chromatographic Method for the Purifi cation of High-Purity Paclitaxel from Taxus chinensis Using Tandem Cavitation Fractional Precipitation

Da-Yeon Kang Jin-Hyun Kim^†

Department of Chemical Engineering, Center for Future Sustainable Technology , Kongju National University , Cheonan 330-717 , South Korea

jinhyun@kongju.ac.kr

Korean Journal of Chemical Engineering, January 2024, 41(1), 285-298(14), https://doi.org/10.1007/s11814-024-00014-7

Abstract

In this study, a non-chromatographic method using tandem cavitation fractional precipitation was developed for the purifi

cation of high-purity paclitaxel. Paclitaxel was purifi ed with a purity of 98.8% and an overall yield of 91.1% through a

three-step fractional precipitation using acetone/pentane (1:9, v/v), methanol/water (61.5:38.5, v/v), and acetone/water (1:2,

v/v) systems. In addition, the precipitation characteristics and step-by-step impurity removal behaviors were observed using

RP-HPLC, and the structure of the paclitaxel purifi ed by tandem cavitation fractional precipitation was identifi ed using

FT-IR spectroscopy.

Keywords

Paclitaxel · Purifi cation · Non-chromatographic process · Tandem cavitation fractional precipitation · Solvent polarity index