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- In relation to this article, we declare that there is no conflict of interest.
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Received October 30, 2023
Accepted January 29, 2024
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Preparation, Characterization, and Application of Electrospun BAG/ CMC/β-CD Nanofi bers for Flutamide Drug Delivery
Abstract
In this study, using a combination of bioactive glass (BAG), carboxymethyl cellulose (CMC), and β-cyclodextrin (β-CD), a
novel nanofi ber network was fabricated through the electrospinning method. The biocompatible BAG/CMC/β-CD nanofi bers
(NF) were optimized for the controlled release of fl utamide, a hydrophobic anticancer drug, which was immobilized on the
surface of nanofi bers through chemical conjugation. The synthesized nanofi bers were characterized by various analytical
techniques, including X-ray diff raction analysis, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy,
the Brunauer–Emmett–Teller specifi c surface area, fi eld emission scanning electron microscopy, energy dispersive X-ray
spectroscopy, transmission electron microscopy, and UV–Vis Spectroscopy. The drug loading and in vitro drug release studies
at a pH of 7.4 investigated the high loading effi ciency at 99.65% and the release without an initial burst of a high dosage of
the drug in a few hours. The drug release achieved 100% within 12 h, following a sustained release pattern due to the slow
degradation of the matrix. The fi ndings suggest that BAG/CMC/β-CD NF could be a promising candidate for the fl utamide
drug delivery system due to overcoming the challenges of its poor bioavailability and low aqueous solubility.
