Metal–organic frameworks (MOFs) are a unique class of porous materials formed by connecting metal ions or clusters within

the organic ligands. They have attracted substantial attention in various fi elds, including drug delivery and their potential

in addressing microbial infections. In this particular research, we accomplished the successful encapsulation of 4-chloro-

3-formylcoumarin (CFC) within potassium-based perylene tetracarboxylic acid (K 4 PTC) MOFs. Our investigation involved

characterizing this process using proton chemical shifts, affi rming the eff ective incorporation of CFC molecules within the

cavities of the MOFs. Moreover, the diff erences between MOFs that had been loaded with CFC and those that remained

unloaded are strikingly evident in scanning electron microscopy (SEM) images. These distinctions allowed us to visually

confi rm the successful loading of CFC into the MOFs. To evaluate the MOFs' antibacterial properties, we conducted experiments

involving two human pathogenic microbes. The results revealed signifi cant zones of growth inhibition corresponding

to the concentration of MOFs used, underscoring their potent antibacterial activity. In addition to these assessments, we

conducted a biofi lm assay to gauge the MOFs' eff ectiveness in countering the formation of biofi lms by these pathogens.