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EFFECTS OF AERATION AND AGITATION ON THE SISOMICIN PRODUCTION BY MICROMONOSPORA INYOENSIS

GIL GH PARK SB LIM JY LEE JH YOO MY

Korean Journal of Chemical Engineering, March 1988, 5(1), 19-22(4), 10.1007/BF02697472

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Abstract

Physical factors affecting the production of sisomicin by Micromonospora inyoensis are presented. A sisomicin productivity was affected significantly by both the degree of aeration and the type of impeller used. In addition, the value of impeller tip speed was found to be an important factor in the sisomicin production. Therefore, scale-up on the basis of impeller tip speed was attempted and satisfactory results were obtained.

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