Articles & Issues
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
All issues
BIOPRODUCT ADSORPTION IN IMMOBILIZED ADSORBENT : LOCAL THERMODYNAMIC EQUILIBRIUM MODEL
Korean Journal of Chemical Engineering, October 1990, 7(4), 269-278(10), 10.1007/BF02707179
Download PDF
Abstract
A mathematical model using local thermodynamic equilibrium isotherms for adsorption on immobilized adsorbents is proposed in order to optimize the design parameters in in situ bioproduct separation process. The model accurately follows the experimental data on the adsorption of berberine, secondary metabolite produced in plant cell culture. The result shows that the lower loading capacity in immobilized adsorbents is due to the decrease in the maximum solid phase concentration and the isotherm equilibrium constant, not the effective diffusivity. Design parameters in in situ bioproduct separation process, such as the size of the beads, the ratio of beads to bulk volume and the adsorbent content of the bead, are evaluated by using the model. The decrease of bead size is the most effective parameter for adsorption of berberine immobilized adsorbent due to a reduction in the overall diffusional resistance.
References
Skinner NE, Walton NJ, Robins RJ, Rhodes MJC, Phytochem., 26, 721 (1987)
Payne GF, Payne NN, Biotechnol. Lett., 10, 187 (1988)
Payne GF, Shuler ML, Biotechnol. Bioeng., 31, 922 (1988)
Choi JW, Ph.D. Dissertation, Rutgers Univ., New Brunswick, U.S.A. (1990)
Nigam SC, Wang HY, "Separation, Recovery and Purification in Biotechnology," (ed. by Asenjo, J.A. and Hong, J.), p. 153, American Chemical Society, Washington D.C. (1986)
Nigam SC, Ph.D. Dissertation, Univ. of Michigan, Ann Arbor, U.S.A. (1988)
Pedersen H, Furler L, Venkatasubramanian K, Prenosil J, Stuker E, Biotechnol. Bioeng., 27, 967 (1985)
Firdaus V, Ph.D. Dissertation, Rutgers Univ., New Brunswick, U.S.A. (1984)
Villadsen JV, Michelsen M, "Solution of Differential Equation Models by Polynomial Approximation," Prentice-Hall, Englewood Cliffs (1978)
Maron MJ, "Numerical Analysis: A Practical Approach," Macmillan Publishing Co., New York (1982)
Tanaka H, Matsumura M, Veliky IA, Biotechnol. Bioeng., 26, 53 (1984)
Metzler CM, Elfring GL, McEwen AJ, Biometrics, 30, 562 (1974)
Seinfeld J, Lapidus L, "Process Modeling Estimation and Identification," Prentice-Hall, Englewood Cliffs (1970)
Paleos J, J. Colloid Interface Sci., 31, 7 (1969)
Payne GF, Payne NN, Biotechnol. Lett., 10, 187 (1988)
Payne GF, Shuler ML, Biotechnol. Bioeng., 31, 922 (1988)
Choi JW, Ph.D. Dissertation, Rutgers Univ., New Brunswick, U.S.A. (1990)
Nigam SC, Wang HY, "Separation, Recovery and Purification in Biotechnology," (ed. by Asenjo, J.A. and Hong, J.), p. 153, American Chemical Society, Washington D.C. (1986)
Nigam SC, Ph.D. Dissertation, Univ. of Michigan, Ann Arbor, U.S.A. (1988)
Pedersen H, Furler L, Venkatasubramanian K, Prenosil J, Stuker E, Biotechnol. Bioeng., 27, 967 (1985)
Firdaus V, Ph.D. Dissertation, Rutgers Univ., New Brunswick, U.S.A. (1984)
Villadsen JV, Michelsen M, "Solution of Differential Equation Models by Polynomial Approximation," Prentice-Hall, Englewood Cliffs (1978)
Maron MJ, "Numerical Analysis: A Practical Approach," Macmillan Publishing Co., New York (1982)
Tanaka H, Matsumura M, Veliky IA, Biotechnol. Bioeng., 26, 53 (1984)
Metzler CM, Elfring GL, McEwen AJ, Biometrics, 30, 562 (1974)
Seinfeld J, Lapidus L, "Process Modeling Estimation and Identification," Prentice-Hall, Englewood Cliffs (1970)
Paleos J, J. Colloid Interface Sci., 31, 7 (1969)
