ISSN: 0256-1115 (print version) ISSN: 1975-7220 (electronic version)
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In relation to this article, we declare that there is no conflict of interest.
Publication history
Received April 30, 2024
Accepted August 24, 2024
articles This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Most Cited

Recent Developments in Near-Infrared-II Luminescence Imaging Using Inorganic Nanoparticles: Semiconductor Quantum Dots and Lanthanide Nanoparticles

School of Chemical Engineering , Chonnam National University 1Institute of Industrial Nanomaterials (IINa) , Kumamoto University 2International Research Organization for Advanced Science and Technology (IROAST) 3Faculty of Advanced Science and Technology (FAST) , Kumamoto University
Korean Journal of Chemical Engineering, December 2024, 41(13), 3603-3619(17), https://doi.org/10.1007/s11814-024-00300-4

Abstract

Fluorescence imaging fi nds extensive application in cellular and small animal studies due to its superior temporal and

spatial resolution. However, fl uorescence imaging using visible light faces limitations such as shallow tissue penetration,

phototoxicity from excitation sources, and compromised detection sensitivity owing to background autofl uorescence

interference. To address these issues, researchers have explored longer wavelength light, particularly near-infrared-I (NIRI)

in the 700–900 nm range. Moreover, there is growing interest in exploiting NIR-II light, which spans the 1000–1700 nm

range, to enhance the detection sensitivity, resolution, and tissue-penetration depth. In the NIR-II region, light scattering

is minimized, thus enabling deeper tissue penetration of up to ~ 10 mm, along with reduced tissue autofl uorescence. This

facilitates high-sensitivity and high-resolution fl uorescence imaging. The present review highlights inorganic nanoparticlebased

imaging probes characterized by exceptional photostability and easily tunable emission wavelengths, including

quantum dots and lanthanide nanoparticles. Specifi cally, recent advancements in improving the luminescence effi ciency of

NIR-II quantum dots and lanthanide nanoparticles, tuning the emission wavelengths to longer ranges, and designing stimuliresponsive

mechanisms for precise targeted imaging are discussed.

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